Synthesis of poly(vinyl alcohol) containing asymmetric nucleic acid base derivatives as grafted pendants

Abstract

The preparations of new model polymers of polynucleotides with linear poly(vinyl alcohol) (PVA) backbones and an optically active nucleic acid base derivative as a pending side chain are described. (±)-, (+)-, and (−)-2-(thymin-1-yl)propionic acid were grafted onto PVA through ester bonds by direct coupling with dicyclohexylcarbodiimide (DCC) in the presence of highly active catalyst 4-pyrrolidinopyridine (PPY) to give optically active graft polymers. The corresponding monomer and dimer models have been prepared.