Percutaneous Absorption of Biologically-Active Interferon-gamma in a Human Skin Graft-Nude Mouse Model

Percutaneous Absorption of Biologically-Active Interferon-gamma in a Human Skin Graft-Nude Mouse Model

Weiner, Norman D.; Turner, Jason H.; Paasch, Brian D.; Short, Sarah M.; Daugherty, Ann L.

1996-07

Citation: Short, Sarah M.; Paasch, Brian D.; Turner, Jason H.; Weiner, Norman; Daugherty, Ann L.; (1996). "Percutaneous Absorption of Biologically-Active Interferon-gamma in a Human Skin Graft-Nude Mouse Model." Pharmaceutical Research 13 (7): 1020-1027. <http://hdl.handle.net/2027.42/41453>

Abstract: Purpose . Topical delivery has been suggested to reduce systemic side effects while targeting cytokines for the treatment of certain skin conditions. Liposomes have been proposed as an enhancing agent for such a delivery. We have tested the potential of liposomes to augment the uptake of biologically active recombinant human interferon-gamma (rhIFN-γ) into human skin lacking adnexa in an in vivo model.

ISSN: 1573-904X, 0724-8741

DOIs: http://dx.doi.org/10.1023/A:1016050422634

PMID: 8842039

URI: http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8842039&dopt=citation

Handle: http://hdl.handle.net/2027.42/41453

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