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Overexpression of Human Intestinal Oligopeptide Transporter in Mammalian Cells via Adenoviral Transduction

dc.contributor.authorHsu, Cheng-Pangen_US
dc.contributor.authorRoessler, Blake J.en_US
dc.contributor.authorHilfinger, John M.en_US
dc.contributor.authorWalter, Elkeen_US
dc.contributor.authorMerkle, Hans P.en_US
dc.contributor.authorAmidon, Gordon L.en_US
dc.date.accessioned2006-09-08T19:17:36Z
dc.date.available2006-09-08T19:17:36Z
dc.date.issued1998-09en_US
dc.identifier.citationHsu, Cheng-Pang; Hilfinger, John M.; Walter, Elke; Merkle, Hans P.; Roessler, Blake J.; Amidon, Gordon L.; (1998). "Overexpression of Human Intestinal Oligopeptide Transporter in Mammalian Cells via Adenoviral Transduction." Pharmaceutical Research 15(9): 1376-1381. <http://hdl.handle.net/2027.42/41470>en_US
dc.identifier.issn0724-8741en_US
dc.identifier.issn1573-904Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/41470
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9755888&dopt=citationen_US
dc.description.abstractPurpose . Our goals are to establish an in vitro screening system and to evaluate a new approach in improving oral absorption of peptides and peptide-like drugs by overexpression of the human intestinal oligo-peptide transporter (hPepTl). This study characterizes the expression of hPepTl in human intestinal Caco-2 cells, rat intestinal epithelial cells (IEC-18), and human cervix epithelial cells (Hela) after adenoviral transduction.en_US
dc.format.extent582908 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherBiomedical Engineeringen_US
dc.subject.otherHPepTlen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherPharmacyen_US
dc.subject.otherCaco-2 Cellsen_US
dc.subject.otherDrug Screeningen_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherMedical Lawen_US
dc.subject.otherGene Expressionen_US
dc.subject.otherAdenovirusen_US
dc.titleOverexpression of Human Intestinal Oligopeptide Transporter in Mammalian Cells via Adenoviral Transductionen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumCollege of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065en_US
dc.contributor.affiliationumDepartment of Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumCollege of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065en_US
dc.contributor.affiliationotherDepartment of Pharmacy, ETH Zurich, CH-8057, Zurich, Switzerlanden_US
dc.contributor.affiliationotherDepartment of Pharmacy, ETH Zurich, CH-8057, Zurich, Switzerlanden_US
dc.contributor.affiliationotherTSRL, Incorporated, Ann Arbor, Michigan, 48108en_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid9755888en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/41470/1/11095_2004_Article_303989.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1023/A:1011993303397en_US
dc.identifier.sourcePharmaceutical Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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