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Targeting and Blocking B7 Costimulatory Molecules on Antigen-Presenting Cells Using CTLA4Ig-Conjugated Liposomes: In Vitro Characterization and in Vivo Factors Affecting Biodistribution

dc.contributor.authorPark, Chung-Gyuen_US
dc.contributor.authorThiex, Natalie W.en_US
dc.contributor.authorLee, Kyung-Dallen_US
dc.contributor.authorBluestone, Jeffery A.en_US
dc.contributor.authorSzot, Gregory L.en_US
dc.contributor.authorLee, Kyung-Mien_US
dc.date.accessioned2006-09-08T19:19:34Z
dc.date.available2006-09-08T19:19:34Z
dc.date.issued2003-08en_US
dc.identifier.citationPark, Chung-Gyu; Thiex, Natalie W.; Lee, Kyung-Mi; Szot, Gregory L.; Bluestone, Jeffery A.; Lee, Kyung-Dall; (2003). "Targeting and Blocking B7 Costimulatory Molecules on Antigen-Presenting Cells Using CTLA4Ig-Conjugated Liposomes: In Vitro Characterization and in Vivo Factors Affecting Biodistribution." Pharmaceutical Research 20(8): 1239-1248. <http://hdl.handle.net/2027.42/41500>en_US
dc.identifier.issn1573-904Xen_US
dc.identifier.issn0724-8741en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/41500
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12948022&dopt=citationen_US
dc.description.abstractPurpose. CTLA4Ig, a fusion protein of CTLA-4 and Fc of immunoglobulin (Ig) heavy chain, inhibits the essential costimulatory signal for full T cell activation via blocking the interaction between CD28 and B7 molecules and renders T cell nonresponsiveness. CTLA4Ig has been used to control deleterious T cell activation in many experimental systems. We hypothesized that by conjugating CTLA4Ig to liposomes the efficacy of CTLA4Ig could be enhanced through multivalent ligand effect, superior targetability, and modification of the fate of ligated costimulatory molecules.en_US
dc.format.extent166335 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherIslet Transplantationen_US
dc.subject.otherCTLA4Igen_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherPharmacyen_US
dc.subject.otherBiomedical Engineeringen_US
dc.subject.otherB7 Costimulatory Moleculesen_US
dc.subject.otherTargetingen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.subject.otherLiposomesen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherMedical Lawen_US
dc.titleTargeting and Blocking B7 Costimulatory Molecules on Antigen-Presenting Cells Using CTLA4Ig-Conjugated Liposomes: In Vitro Characterization and in Vivo Factors Affecting Biodistributionen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109-1065; UCSF Diabetes Center, University of California, San Francisco, California, 94143-0540; Department of Microbiology and Immunology, The Transplantation Research Institute, Seoul National University College of Medicine, Seoul, 110-799, Koreaen_US
dc.contributor.affiliationumDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109-1065en_US
dc.contributor.affiliationotherUCSF Diabetes Center, University of California, San Francisco, California, 94143-0540en_US
dc.contributor.affiliationotherUCSF Diabetes Center, University of California, San Francisco, California, 94143-0540en_US
dc.contributor.affiliationotherUCSF Diabetes Center, University of California, San Francisco, California, 94143-0540en_US
dc.contributor.affiliationotherThe Committee on Immunology, Department of Pathology, University of Chicago, Chicago, Illinois, 60637en_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid12948022en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/41500/1/11095_2004_Article_468685.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1023/A:1025057216492en_US
dc.identifier.sourcePharmaceutical Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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