Comparison of Canine and Human Gastrointestinal Physiology
dc.contributor.author | Dressman, Jennifer B. | en_US |
dc.date.accessioned | 2006-09-08T19:20:21Z | |
dc.date.available | 2006-09-08T19:20:21Z | |
dc.date.issued | 1986-06 | en_US |
dc.identifier.citation | Dressman, Jennifer B.; (1986). "Comparison of Canine and Human Gastrointestinal Physiology." Pharmaceutical Research 3(3): 123-131. <http://hdl.handle.net/2027.42/41512> | en_US |
dc.identifier.issn | 0724-8741 | en_US |
dc.identifier.issn | 1573-904X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41512 | |
dc.description.abstract | In this review, the gross physiology of the gastrointestinal tract of dogs is compared with that of humans, particularly as it pertains to drug absorption and dosage-form performance. Gastrointestinal (GI) motility and pH are the main parameters considered. Although similar motility patterns and pH profiles prevail in the two species for the most part, there are some differences that could affect the time profile and extent of drug absorption. These include slower gastric emptying in the fed state, faster small intestine transit, and higher and more variable intestinal pH in dogs compared with humans. An attempt is made to identify drug and dosage-form properties that would lead to differences in drug absorption in the two species, e.g., drug physicochemical properties, dosage-form size, and pH dependency of dosage-form release characteristics. | en_US |
dc.format.extent | 1544511 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Drug Absorption | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Gastrointestinal Drug Absorption | en_US |
dc.subject.other | Medical Law | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Gastrointestinal Mobility and PH | en_US |
dc.subject.other | Gastrointestinal Tract, Dogs | en_US |
dc.title | Comparison of Canine and Human Gastrointestinal Physiology | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065 | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 24271517 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41512/1/11095_2004_Article_306447.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1016353705970 | en_US |
dc.identifier.source | Pharmaceutical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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