The Effect of Physical Aging on the Dissolution Rate of Anionic Polyelectrolytes
dc.contributor.author | Sinko, Christopher M. | en_US |
dc.contributor.author | Yee, Albert F. | en_US |
dc.contributor.author | Amidon, Gordon L. | en_US |
dc.date.accessioned | 2006-09-08T19:22:38Z | |
dc.date.available | 2006-09-08T19:22:38Z | |
dc.date.issued | 1990-06 | en_US |
dc.identifier.citation | Sinko, Christopher M.; Yee, Albert F.; Amidon, Gordon L.; (1990). "The Effect of Physical Aging on the Dissolution Rate of Anionic Polyelectrolytes." Pharmaceutical Research 7(6): 648-653. <http://hdl.handle.net/2027.42/41547> | en_US |
dc.identifier.issn | 1573-904X | en_US |
dc.identifier.issn | 0724-8741 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41547 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2367333&dopt=citation | en_US |
dc.description.abstract | The effect of physical aging on the dissolution and mechanical properties of hydroxypropyl methyl-cellulose phthalate (HPMCP) was investigated. Dissolution rate measurements were performed on films which, initially above the glass transition temperature, T g , were quenched to a sub- T g storage temperature, aged at that temperature for a period of time and then quenched again to 25°C. Within the time scale of observation, reductions in the dissolution rate to a limiting value were observed. HPMCP was also found to age in the same storage temperature range as determined by a creep compliance technique. These mechanical results indicate a change in glass structure and show that a limiting density was approached. Parallel changes were observed in the dissolution rate studies suggest that dissolution rate is governed in part by glass density. Therefore, mechanical changes of glassy films can yield pharmaceutically relevant information about the extent of physical aging and serve as an indicator of the effect of aging on dissolution rate. | en_US |
dc.format.extent | 944355 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Hydroxypropyl Methylcellulose Phthalate | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Medical Law | en_US |
dc.subject.other | Dissolution | en_US |
dc.subject.other | Physical Aging | en_US |
dc.subject.other | Enteric Coating | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Creep Compliance | en_US |
dc.title | The Effect of Physical Aging on the Dissolution Rate of Anionic Polyelectrolytes | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065 | en_US |
dc.contributor.affiliationum | Department of Materials Science and Engineering, The University of Michigan, Ann Arbor, Michigan, 48109-1065 | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065; Drug Delivery R&D-Pharmaceutics, The Upjohn Company, Kalamazoo, Michigan, 49001 | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 2367333 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41547/1/11095_2004_Article_305781.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1015882631082 | en_US |
dc.identifier.source | Pharmaceutical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.