Influence of Physical Aging on Mechanical Properties of Polymer Free Films: The Prediction of Long-Term Aging Effects on the Water Permeability and Dissolution Rate of Polymer Film-Coated Tablets
dc.contributor.author | Amidon, Gordon L. | en_US |
dc.contributor.author | Guo, Jian-Hwa | en_US |
dc.contributor.author | Robertson, Richard E. | en_US |
dc.date.accessioned | 2006-09-08T19:23:18Z | |
dc.date.available | 2006-09-08T19:23:18Z | |
dc.date.issued | 1991-12 | en_US |
dc.identifier.citation | Guo, Jian-Hwa; Robertson, Richard E.; Amidon, Gordon L.; (1991). "Influence of Physical Aging on Mechanical Properties of Polymer Free Films: The Prediction of Long-Term Aging Effects on the Water Permeability and Dissolution Rate of Polymer Film-Coated Tablets." Pharmaceutical Research 8(12): 1500-1504. <http://hdl.handle.net/2027.42/41557> | en_US |
dc.identifier.issn | 1573-904X | en_US |
dc.identifier.issn | 0724-8741 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41557 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1808613&dopt=citation | en_US |
dc.description.abstract | The effects of physical aging on the water permeation of cellulose acetate and ethylcellulose, the mechanical properties of ethylcellulose, and the dissolution property of hydroxypropyl methylcellulose phthalate were investigated. The water permeabilities of cellulose acetate and ethylcellulose and the dissolution rate of hydroxypropyl methylcellulose phthalate were found to decrease with physical aging time after being quenched from above the glass transition temperatures to sub- T g temperatures. The gradual approach toward thermodynamic equilibrium during physical aging decreases the free volume of the polymers. This decrease in free volume is accompanied by a decrease in the transport mobility, with concomitant changes in those properties of the polymer that depend on it. The effects of long-term aging on the dissolution rate and water permeabilities of these polymers can be estimated from a linear double-logarithmic relationship between the mobility properties and physical aging time. The existence of the linear double-logarithmic relationship can be derived from the Williams–Landel–Ferry (1) equation, the Doolittle (2) equation, Struik's (3) model, and Fujita's (4) relationship between diffusion and free volume. | en_US |
dc.format.extent | 819828 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Creep Compliance | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Medical Law | en_US |
dc.subject.other | Glass Transition Temperature | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Dissolution Rate | en_US |
dc.subject.other | Permeability | en_US |
dc.subject.other | Physical Aging | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.title | Influence of Physical Aging on Mechanical Properties of Polymer Free Films: The Prediction of Long-Term Aging Effects on the Water Permeability and Dissolution Rate of Polymer Film-Coated Tablets | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065; The Upjohn Company, Kalamazoo, Michigan, 49001 | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065 | en_US |
dc.contributor.affiliationum | Department of Materials Science and Engineering, The University of Michigan, Ann Arbor, Michigan, 48109-2136 | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 1808613 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41557/1/11095_2004_Article_305639.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1015890232106 | en_US |
dc.identifier.source | Pharmaceutical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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