Role of endothelial cell survival and death signals in angiogenesis
dc.contributor.author | Polverini, Peter J. | en_US |
dc.contributor.author | Nör, Jacques E. | en_US |
dc.date.accessioned | 2006-09-08T19:36:37Z | |
dc.date.available | 2006-09-08T19:36:37Z | |
dc.date.issued | 1999-03 | en_US |
dc.identifier.citation | Nör, Jacques E.; Polverini, Peter J.; (1999). "Role of endothelial cell survival and death signals in angiogenesis." Angiogenesis 3(2): 101-116. <http://hdl.handle.net/2027.42/41762> | en_US |
dc.identifier.issn | 0969-6970 | en_US |
dc.identifier.issn | 1573-7209 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41762 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=14517428&dopt=citation | en_US |
dc.description.abstract | Angiogenesis, the process of new microvessel development, is encountered in a select number of physiological processes and is central to the pathogenesis of a wide variety of diseases. There is now convincing evidence that regulated patterns of endothelial cell survival and death, a process known as apoptosis, play a central role in the periodic remodeling of the vasculature, and in the timely evolution and regression of angiogenic responses. In this review we discuss the current evidence suggesting a role for inducers and inhibitors of angiogenesis as well as other mediators that modify endothelial cells functions in the survival and death of endothelial cells. We also discuss how dysregulation of apoptosis can lead to aberrant angiogenesis as demonstrated in the pathogenesis of retinopathy of prematurity and cancer. | en_US |
dc.format.extent | 241973 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Springer Science+Business Media | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Cardiology | en_US |
dc.subject.other | Oncology | en_US |
dc.subject.other | Ophthalmology | en_US |
dc.subject.other | Angiogenesis | en_US |
dc.subject.other | Apoptosis | en_US |
dc.subject.other | Cell Death | en_US |
dc.subject.other | Endothelial Cell | en_US |
dc.subject.other | Neovascularization | en_US |
dc.title | Role of endothelial cell survival and death signals in angiogenesis | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Oral Medicine/Pathology/Oncology, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA; Department of Orthodontics and Pediatric Dentistry, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Oral Medicine/Pathology/Oncology, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 14517428 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41762/1/10456_2004_Article_255969.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1009053411094 | en_US |
dc.identifier.source | Angiogenesis | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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