Oral self-administration of ethanol, phencyclidine, methadone, pentobarbital and quinine in rhesus monkeys
dc.contributor.author | Vivian, Jeffrey A. | en_US |
dc.contributor.author | Linnoila, Markku | en_US |
dc.contributor.author | Higley, J. D. | en_US |
dc.contributor.author | Woods, James H. | en_US |
dc.contributor.author | Liang, Y. J. | en_US |
dc.date.accessioned | 2006-09-08T19:49:49Z | |
dc.date.available | 2006-09-08T19:49:49Z | |
dc.date.issued | 1999-11 | en_US |
dc.identifier.citation | Vivian, J. A.; Liang, Y. J.; Higley, J. D.; Linnoila, M.; Woods, J. H.; (1999). "Oral self-administration of ethanol, phencyclidine, methadone, pentobarbital and quinine in rhesus monkeys." Psychopharmacology 147(2): 113-124. <http://hdl.handle.net/2027.42/41968> | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41968 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10591878&dopt=citation | en_US |
dc.description.abstract | Rationale: Simultaneous and sequential drug use among clinical populations is the norm, whereas the pattern of self-administration of multiple drugs among non-human primate populations has not been thoroughly explored. Objectives: To determine the relationship between the preferences and intakes of a large group of rhesus monkeys exposed to various orally available solutions. Methods: Thirteen male and eleven female young adult rhesus monkeys ( Macaca mulatta ) were exposed to orally available drug solutions using a concurrent choice (drug and water) procedure, where fluid delivery was made contingent upon single spout contacts (fixed ratio one). Results: Ethanol (0.25–16% w:v) produced biphasic effects on the number of fluid deliveries obtained, with peak ethanol preferences over water demonstrated at the 1–2% w:v concentrations. No preferences for the N -methyl- d -aspartate receptor antagonist phencyclidine or water were demonstrated at lower concentrations (0.0078125–0.125 mg/ml) and, at higher concentrations (0.25, 0.5 mg/ml), a preference for water was demonstrated. The µ opioid receptor agonist methadone (0.001–0.3 mg/ml) and the prototypic bitter substance quinine (0.001–0.3 mg/ml) failed to produce preferences for drug or water. A large preference for water over the barbiturate pentobarbital (0.01–3 mg/ml) was also demonstrated. After rank-ordering the subjects based on their drug preferences or intakes, modest to no correlations across drugs were demonstrated. Conclusions: These results reveal that a robust ethanol preference is not predictive of a preference for drugs of abuse from other classes and suggests that fluid intakes were correlated, irrespective of the presence or absence of drug in the solution. | en_US |
dc.format.extent | 159846 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag Berlin Heidelberg | en_US |
dc.subject.other | Opiates | en_US |
dc.subject.other | Legacy | en_US |
dc.subject.other | Quinine | en_US |
dc.subject.other | Individual Differences | en_US |
dc.subject.other | NMDA | en_US |
dc.subject.other | Key Words Barbiturates | en_US |
dc.subject.other | Ethanol | en_US |
dc.subject.other | Preferences | en_US |
dc.subject.other | Self-administration | en_US |
dc.title | Oral self-administration of ethanol, phencyclidine, methadone, pentobarbital and quinine in rhesus monkeys | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, 1301, MSRB III, Ann Arbor, MI 48109-0632, USA e-mail: jvivian@umich.edu, Tel.: +1-734-6473119, Fax: +1-734-7647118, US, | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, 1301, MSRB III, Ann Arbor, MI 48109-0632, USA e-mail: jvivian@umich.edu, Tel.: +1-734-6473119, Fax: +1-734-7647118, US, | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, 1301, MSRB III, Ann Arbor, MI 48109-0632, USA e-mail: jvivian@umich.edu, Tel.: +1-734-6473119, Fax: +1-734-7647118, US, | en_US |
dc.contributor.affiliationother | Laboratory of Clinical Studies – Primate Unit, DICBR, NIAAA, NIH, Poolesville, Maryland, USA, US, | en_US |
dc.contributor.affiliationother | Laboratory of Clinical Studies – Primate Unit, DICBR, NIAAA, NIH, Poolesville, Maryland, USA, US, | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 10591878 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41968/1/213-147-2-113_91470113.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s002130051151 | en_US |
dc.identifier.source | Psychopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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