Modulation of morphine sensitization in the rat by contextual stimuli
dc.contributor.author | Robinson, Terry E. | en_US |
dc.contributor.author | Oates, M. M. | en_US |
dc.contributor.author | Badiani, Aldo | en_US |
dc.date.accessioned | 2006-09-08T19:50:08Z | |
dc.date.available | 2006-09-08T19:50:08Z | |
dc.date.issued | 2000-08 | en_US |
dc.identifier.citation | Badiani, A.; Oates, M. M.; Robinson, T. E.; (2000). "Modulation of morphine sensitization in the rat by contextual stimuli." Psychopharmacology 151 (2-3): 273-282. <http://hdl.handle.net/2027.42/41973> | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41973 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10972474&dopt=citation | en_US |
dc.description.abstract | Rationale: The repeated administration of addictive drugs, such as amphetamine, cocaine, and morphine, produces a progressive enhancement (sensitization) of their psychomotor activating effects. We have previously shown that administration of amphetamine or cocaine in a distinct test environment promotes more robust psychomotor sensitization than if they are given at home. No information is available, however, on whether this environmental manipulation has a similar effect on sensitization to morphine, a drug that enhances dopamine (DA) release in the striatum indirectly by disinhibiting midbrain DA neurons. Objectives: The main goal of present study was to determine whether exposure to a distinct environmental context facilitates morphine sensitization. Methods: As an index of psychomotor activation, we used rotational behavior in rats with a uni- lateral 6-hydroxydopamine lesion of the mesostriatal DA system. There are inconsistencies in the literature regarding the ability of morphine to elicit rotational behavior. Therefore, in experiment 1 we determined the effect of 2.0, 3.0, 4.0, 6.0, and 8.0 mg/kg, IP, of morphine on rotational behavior. In experiment 2, we studied the effect of five consecutive IV infusions of saline or morphine (2.0 mg/kg) in rats treated either in their home cage or in a distinct and relatively novel test environment. After 5 days of withdrawal, all rats received an IV infusion of 2.0 mg/kg morphine (Morphine challenge). The following day all rats received an IV infusion of saline (Saline challenge). Results: Morphine produced a dose-dependent increase in rotational behavior. Environmental novelty enhanced both the acute psychomotor response to morphine and its ability to induce psychomotor sensitization. Furthermore, a conditioned rotational response was seen only in animals treated in the novel environment. Conclusions: Environmental novelty can facilitate the development of sensitization to the psychomotor activating effects of major addictive drugs, such as amphetamine, cocaine, and morphine. | en_US |
dc.format.extent | 98943 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag Berlin Heidelberg | en_US |
dc.subject.other | Associative Learning | en_US |
dc.subject.other | Rotational Behavior | en_US |
dc.subject.other | Context | en_US |
dc.subject.other | 6-OHDA | en_US |
dc.subject.other | Nucleus Accumbens | en_US |
dc.subject.other | Sensitization | en_US |
dc.subject.other | Novelty | en_US |
dc.subject.other | Legacy | en_US |
dc.subject.other | Keywords Morphine | en_US |
dc.subject.other | Psychomotor Activity | en_US |
dc.subject.other | Stress | en_US |
dc.subject.other | Environment | en_US |
dc.subject.other | Conditioning | en_US |
dc.subject.other | Mesostriatal Dopamine System | en_US |
dc.subject.other | Dopamine | en_US |
dc.title | Modulation of morphine sensitization in the rat by contextual stimuli | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Neuroscience and Biopsychology Programs, The University of Michigan, Ann Arbor, Michigan, USA, US | en_US |
dc.contributor.affiliationum | Neuroscience and Biopsychology Programs, The University of Michigan, Ann Arbor, Michigan, USA, US | en_US |
dc.contributor.affiliationum | Neuroscience and Biopsychology Programs, The University of Michigan, Ann Arbor, Michigan, USA, US | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 10972474 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41973/1/213-151-2-3-273_01510273.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s002130000447 | en_US |
dc.identifier.source | Psychopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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