Improving postoperative MR imaging of pituitary macroadenomas: comparison of full and reduced dose of gadopentetate dimeglumine
dc.contributor.author | Eldevik, O. Petter | en_US |
dc.contributor.author | Pedersen, H. K. | en_US |
dc.contributor.author | Hald, J. K. | en_US |
dc.contributor.author | Nakstad, P. H. | en_US |
dc.contributor.author | Dunn, Rodney L. | en_US |
dc.contributor.author | Bakke, S. J. | en_US |
dc.date.accessioned | 2006-09-08T19:58:51Z | |
dc.date.available | 2006-09-08T19:58:51Z | |
dc.date.issued | 2000-06 | en_US |
dc.identifier.citation | Hald, J. K.; Eldevik, O. P.; Dunn, R. L.; Bakke, S. J.; Pedersen, H. K.; Nakstad, P. H.; (2000). "Improving postoperative MR imaging of pituitary macroadenomas: comparison of full and reduced dose of gadopentetate dimeglumine." European Radiology 10(7): 1068-1072. <http://hdl.handle.net/2027.42/42110> | en_US |
dc.identifier.issn | 0938-7994 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42110 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11003399&dopt=citation | en_US |
dc.description.abstract | The aim of this study was to evaluate the efficacy of contrast-medium (CM)-enhanced MR imaging of operated pituitary macroadenomas with reduced dose of gadopentetate dimeglumine. In a prospective study 18 patients were examined with coronal T1-weighted MR imaging prior to and following intravenous CM injections. Two sets of contrast-enhanced coronal images were obtained in each patient; the first set after 50 % of the recommended dose of 0.1 mmol/kg body weight (b. w.) had been administered, and the second set immediately after additional CM had been given to make up a total dose of 0.1 mmol/kg b. w. The images were evaluated by three neuroradiologists. The SIPAP classification system was used to evaluate tumour extension, whereas tumour margin conspicuity was scored using an arbitrary scale of 1–5 (1 = indistinct, 5 = well defined). Signal intensity measurements obtained from the most enhancing part of the adenomas demonstrated increased enhancement with increased CM dose. Tumour delineation scores were significantly better on the reduced- and full-dose images than on pre-CM injection images, but, with one exception, tumour extension was identified as the same on all imaging sequences. Postoperative MR imaging of large macroadenoma residues can routinely be performed without intravenous CM. When CM is indicated a reduced dose of gadopentetate dimeglumine should provide sufficient diagnostic information. | en_US |
dc.format.extent | 655127 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag Berlin Heidelberg | en_US |
dc.subject.other | Legacy | en_US |
dc.subject.other | Key Words: Magnetic Resonance Imaging – Contrast Medium – Cost Benefit – Surgically Treated Macroadenomas | en_US |
dc.title | Improving postoperative MR imaging of pituitary macroadenomas: comparison of full and reduced dose of gadopentetate dimeglumine | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Radiology | en_US |
dc.subject.hlbsecondlevel | Family Medicine and Primary Care | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Cancer Center Biostatistics Unit, University of Michigan, Ann Arbor, 48109–0030 Michigan, USA, US | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan, Ann Arbor, 48109–0030 Michigan, USA, US | en_US |
dc.contributor.affiliationother | Department of Radiology, Rikshospitalet, The National Hospital, N-0027 Oslo, Norway, NO | en_US |
dc.contributor.affiliationother | Department of Radiology, Rikshospitalet, The National Hospital, N-0027 Oslo, Norway, NO | en_US |
dc.contributor.affiliationother | Department of Radiology, Rikshospitalet, The National Hospital, N-0027 Oslo, Norway, NO | en_US |
dc.contributor.affiliationother | Department of Radiology, Rikshospitalet, The National Hospital, N-0027 Oslo, Norway, NO | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 11003399 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42110/1/330-10-7-1068_00101068.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s003300000455 | en_US |
dc.identifier.source | European Radiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.