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Optochemical Nanosensors and Subcellular Applications in Living Cells

dc.contributor.authorKopelman, Raoulen_US
dc.contributor.authorPhilbert, Martin A.en_US
dc.contributor.authorClark, Heather A.en_US
dc.contributor.authorHoyer, Marion E.en_US
dc.contributor.authorParus, Stephan J.en_US
dc.date.accessioned2006-09-08T20:21:03Z
dc.date.available2006-09-08T20:21:03Z
dc.date.issued1999-06en_US
dc.identifier.citationClark, Heather A.; Hoyer, Marion; Parus, Steve; Philbert, Martin A.; Kopelman, Raoul; (1999). "Optochemical Nanosensors and Subcellular Applications in Living Cells." Mikrochimica Acta 131 (1-2): 121-128. <http://hdl.handle.net/2027.42/42448>en_US
dc.identifier.issn0026-3672en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/42448
dc.description.abstract What may be the smallest anthropogenic devices to date, spherical sensors (wireless and fiberless) with radii as small as 10 nm have been produced. This class of optochemical PEBBLE (Probe Encapsulated By Biologically Localized Embedding) sensors covers a wide range of analytes (pH, calcium, oxygen and potassium included here) with excellent spatial, temporal and chemical resolution. Examples of such sensors for the monitoring of intracellular analytes are given. Methods, such as pico-injection, liposomal delivery and gene gun bombardment, are used to inject PEBBLE sensors into single cells. These PEBBLEs have caused minimal perturbation when delivered and operated inside single mammalian cells, such as human neuroblastoma, mouse oocytes or rat alveolar macrophage.en_US
dc.format.extent455291 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlag; Springer-Verlag Wienen_US
dc.subject.otherLegacyen_US
dc.subject.otherKey Words: Optodes; Nanosensor; Cellular Probes; Sensors.en_US
dc.titleOptochemical Nanosensors and Subcellular Applications in Living Cellsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMaterials Science and Engineeringen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationum Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA, USen_US
dc.contributor.affiliationum Department of Environmental and Industrial Health, University of Michigan, MI, USA, USen_US
dc.contributor.affiliationum Department of Environmental and Industrial Health, University of Michigan, MI, USA, USen_US
dc.contributor.affiliationum Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA, USen_US
dc.contributor.affiliationum Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA, USen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/42448/1/604-131-1-2-121_91310121.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s006040050017en_US
dc.identifier.sourceMikrochimica Actaen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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