Familial aggregation of melanoma risks in a large population-based sample of melanoma cases
dc.contributor.author | Begg, Colin B. | en_US |
dc.contributor.author | Hummer, Amanda | en_US |
dc.contributor.author | Mujumdar, Urvi | en_US |
dc.contributor.author | Armstrong, Bruce K. | en_US |
dc.contributor.author | Kricker, Anne | en_US |
dc.contributor.author | Marrett, Loraine D. | en_US |
dc.contributor.author | Millikan, Robert C. | en_US |
dc.contributor.author | Gruber, Stephen B. | en_US |
dc.contributor.author | Anton-Culver, Hoda | en_US |
dc.contributor.author | Klotz, Judith B. | en_US |
dc.contributor.author | Zanetti, Roberto | en_US |
dc.contributor.author | Gallagher, Richard P. | en_US |
dc.contributor.author | Dwyer, Terence | en_US |
dc.contributor.author | Rebbeck, Timothy R. | en_US |
dc.contributor.author | Berwick, Marrianne R. | en_US |
dc.date.accessioned | 2006-09-08T20:26:28Z | |
dc.date.available | 2006-09-08T20:26:28Z | |
dc.date.issued | 2004-11 | en_US |
dc.identifier.citation | Begg, Colin B.; Hummer, Amanda; Mujumdar, Urvi; Armstrong, Bruce K.; Kricker, Anne; Marrett, Loraine D.; Millikan, Robert C.; Gruber, Stephen B.; Anton-Culver, Hoda; Klotz, Judith B.; Zanetti, Roberto; Gallagher, Richard P.; Dwyer, Terence; Rebbeck, Timothy R.; Berwick, Marrianne R.; (2004). "Familial aggregation of melanoma risks in a large population-based sample of melanoma cases." Cancer Causes and Control 15(9): 957-965. <http://hdl.handle.net/2027.42/42531> | en_US |
dc.identifier.issn | 0957-5243 | en_US |
dc.identifier.issn | 1573-7225 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42531 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15577298&dopt=citation | en_US |
dc.description.abstract | Objective Melanoma has been shown in numerous studies to be associated with sun exposure, and with host phenotypic factors of genetic origin. In this study we use information from a large series of incident cases of melanoma from an international population-based study to examine the patterns of incidence of melanoma in the first-degree relatives of these cases. Methods : A total of 2508 incident cases of melanoma provided information on basic demographic data and pigmentary characteristics, in addition to detailed information on family history of melanoma. These data were used to examine the incidence rates ratios of melanoma in the relatives of cases in relation to population rates, and also with respect to phenotypic characteristics of the probands that have been shown to be associated with melanoma: mole counts, hair color, eye color, and skin sensitivity to the sun. Results : The incidence rates reflect the underlying patterns of incidence in the source populations, with generally higher rates in the Australian sample, low rates in Italy, and intermediate rates in the USA and Canada. Also, rates are higher in men than in women, except at very young ages. Phenotypic characteristics of the probands were only weakly associated with the observed rates in the relatives although there is a strong inverse association with age at diagnosis. Cumulative risk of melanoma rises to 6.9 (6.1) at age 80 in male (female) first-degree relatives of cases, and to 10.8 (9.5) in relatives of cases diagnosed before age 50. Conclusions : Relatives of cases diagnosed with melanoma are at considerable lifetime risk of the disease, especially if the case is diagnosed at a young age. | en_US |
dc.format.extent | 151892 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Springer Science+Business Media | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Public Health/Gesundheitswesen | en_US |
dc.subject.other | Hematology | en_US |
dc.subject.other | Oncology | en_US |
dc.subject.other | Epidemiology | en_US |
dc.subject.other | Analyses | en_US |
dc.subject.other | Cohort | en_US |
dc.subject.other | Melanoma | en_US |
dc.subject.other | Risk Factors | en_US |
dc.title | Familial aggregation of melanoma risks in a large population-based sample of melanoma cases | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Memorial Sloan-Kettering Cancer Center, New York, NY, USA; Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, 307 East 63rd Street, 3rd Floor, New York, NY, 10021, USA | en_US |
dc.contributor.affiliationother | Memorial Sloan-Kettering Cancer Center, New York, NY, USA | en_US |
dc.contributor.affiliationother | Memorial Sloan-Kettering Cancer Center, New York, NY, USA | en_US |
dc.contributor.affiliationother | The University of Sydney, Sydney, NSW, Australia | en_US |
dc.contributor.affiliationother | The University of Sydney, Sydney, NSW, Australia | en_US |
dc.contributor.affiliationother | Cancer Care Ontario, Toronto, Canada | en_US |
dc.contributor.affiliationother | University of North Carolina, Chapel Hill, NC, USA | en_US |
dc.contributor.affiliationother | University of California at Irvine, Irvine, CA, USA | en_US |
dc.contributor.affiliationother | University of Medicine and Dentistry of New Jersey, Piscataway, NJ, USA | en_US |
dc.contributor.affiliationother | Centro per la Prevenzione Oncologia, Torino, Piemonte, Italy | en_US |
dc.contributor.affiliationother | British Columbia Cancer Agency, Vancouver, Canada | en_US |
dc.contributor.affiliationother | University of Tasmania, Hobart, Tasmania, Australia | en_US |
dc.contributor.affiliationother | University of Pennsylvania, Philadelphia, PA, USA | en_US |
dc.contributor.affiliationother | University of New Mexico, Albuquerque, NM, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 15577298 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42531/1/10552_2004_Article_2474.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s10552-004-2474-1 | en_US |
dc.identifier.source | Cancer Causes and Control | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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