Ultrastructural localization of chromogranin: a potential marker for the electron microscopical recognition of endocrine cell secretory granules
dc.contributor.author | Varndell, Ian M. | en_US |
dc.contributor.author | Lloyd, Ricardo V. | en_US |
dc.contributor.author | Wilson, Barry S. | en_US |
dc.contributor.author | Polak, Julia M. | en_US |
dc.date.accessioned | 2006-09-08T20:47:43Z | |
dc.date.available | 2006-09-08T20:47:43Z | |
dc.date.issued | 1985-09 | en_US |
dc.identifier.citation | Varndell, Ian M.; Lloyd, Ricardo V.; Wilson, Barry S.; Polak, Julia M.; (1985). "Ultrastructural localization of chromogranin: a potential marker for the electron microscopical recognition of endocrine cell secretory granules." The Histochemical Journal 17(9): 981-992. <http://hdl.handle.net/2027.42/42853> | en_US |
dc.identifier.issn | 0018-2214 | en_US |
dc.identifier.issn | 1573-6865 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42853 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4066407&dopt=citation | en_US |
dc.description.abstract | Using a monoclonal antibody (LK2H10) directed against human chromogranin, we have been able to localize this soluble glycoprotein to the matrix of secretory granules from a wide variety of endocrine cells. In the gut, enterochromaffin, enteroglucagon, glucose-dependent insulinotropic peptide, gastrin, and neurotensin-containing cells exhibit chromogranin immunoreactivity. In our system, chromogranin-immunoreactive material was restricted to the halo of human pancreatic glucagon-containing secretory granules within A-cells. Chromogranin immunoreactivity was also localized to secretory granules in phaeochromocytomas, gastrinomas, medullary carcinomas of the thyroid and a carotid body tumour (chemodectoma). Chromogranin is proposed as a potential marker for the ultrastructural recognition of endocrine cell secretory granules. | en_US |
dc.format.extent | 2924411 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Chapman and Hall Ltd. ; Springer Science+Business Media | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Biomedicine General | en_US |
dc.subject.other | Cell Biology | en_US |
dc.subject.other | Animal Anatomy / Morphology / Histology | en_US |
dc.subject.other | Biological Microscopy | en_US |
dc.title | Ultrastructural localization of chromogranin: a potential marker for the electron microscopical recognition of endocrine cell secretory granules | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK | en_US |
dc.contributor.affiliationother | Department of Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, W12 0HS, London, UK | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 4066407 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42853/1/10735_2005_Article_BF01417947.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01417947 | en_US |
dc.identifier.source | The Histochemical Journal | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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