Un vivo depletion of murine CD8 positive T cells impairs survival during infection with a highly virulent strain of Cryptococcus neoformans
dc.contributor.author | Mody, Christopher H. | en_US |
dc.contributor.author | Chen, Gwo-Hsiao | en_US |
dc.contributor.author | Jackson, Catherine | en_US |
dc.contributor.author | Curtis, Jeffrey L. | en_US |
dc.contributor.author | Toews, Galen B. | en_US |
dc.date.accessioned | 2006-09-08T21:15:10Z | |
dc.date.available | 2006-09-08T21:15:10Z | |
dc.date.issued | 1994-01 | en_US |
dc.identifier.citation | Mody, Christopher H.; Chen, Gwo-Hsiao; Jackson, Catherine; Curtis, Jeffrey L.; Toews, Galen B.; (1994). "Un vivo depletion of murine CD8 positive T cells impairs survival during infection with a highly virulent strain of Cryptococcus neoformans ." Mycopathologia 125(1): 7-17. <http://hdl.handle.net/2027.42/43267> | en_US |
dc.identifier.issn | 0301-486X | en_US |
dc.identifier.issn | 1573-0832 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/43267 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8028643&dopt=citation | en_US |
dc.description.abstract | Cell-mediated immunity plays an important but incompletely understood role in host defense against Cryptococcus neoformans . Because of their multiple capacities as cytokine-secreting cells, cytotoxic cells, and antigen-specific suppressor cells, CD8 positive T lymphocytes could potentially either enhance or impair host defense against C. neoformans . To determine whether CD8 T cells enhance or inhibit host defence during an infection with a highly virulent strain of C. neoformans , we examined the effect of in vivo CD8 cell depletion on suNival and on the number of organisms in mice infected by either the intratracheal or intravenous routes. Adequacy of depletion was confirmed both phenotypically and functionally. Regardless of the route of infection, we found that survival of mice depleted of CD8 T cells was significantly reduced compared to undepleted mice. Surprisingly, however, CD8 depletion did not alter organism burden measured by quantitative CFU assay in mice infected by either route. These data demonstrate that CD8 positive T cells participate in the immune response to a highly virulent strain of C. neoformans . By contrast to minimally virulent isolates that do not cause a life threatening infection, the immune response to a highly virulent isolate does not alter the burden of organisms, but does enhance host defense as it is necessary for the optimal survival of infected mice. | en_US |
dc.format.extent | 1132802 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Springer Science+Business Media | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Medical Microbiology | en_US |
dc.subject.other | Microbial Ecology | en_US |
dc.subject.other | Microbiology | en_US |
dc.subject.other | Plant Sciences | en_US |
dc.subject.other | Cryptococcus | en_US |
dc.subject.other | Host Defense | en_US |
dc.subject.other | Lymphocyte Subsets | en_US |
dc.subject.other | Mice | en_US |
dc.subject.other | Mixed Lymphocyte Reaction | en_US |
dc.title | Un vivo depletion of murine CD8 positive T cells impairs survival during infection with a highly virulent strain of Cryptococcus neoformans | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Pulmonary & Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Division of Pulmonary & Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Division of Pulmonary & Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA; Department of Veterans Affairs Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Division of Pulmonary & Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA; Department of Veterans Affairs Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Internal Medicine, University of Calgary, Calgary, Alberta, Canada; Division of Pulmonary Medicine, Room 273 HMRB; 3330 Hospital Drive NW, University of Calgary, T2N 4N1, Calgary, Alberta, Canada | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 8028643 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/43267/1/11046_2005_Article_BF01103969.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01103969 | en_US |
dc.identifier.source | Mycopathologia | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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