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The fungicidal activity of novel nanoemulsion (X8W 60 PC) against clinically important yeast and filamentous fungi

dc.contributor.authorMyc, Andrzejen_US
dc.contributor.authorVanhecke, Thomasen_US
dc.contributor.authorLanders, Jeffrey J.en_US
dc.contributor.authorHamouda, Tareken_US
dc.contributor.authorBaker, James R. Jr.en_US
dc.date.accessioned2006-09-08T21:15:33Z
dc.date.available2006-09-08T21:15:33Z
dc.date.issued2003-05en_US
dc.identifier.citationMyc, Andrzej; Vanhecke, Thomas; Landers, Jeffrey J.; Hamouda, Tarek; Baker, James R.; (2003). "The fungicidal activity of novel nanoemulsion (X8W 60 PC) against clinically important yeast and filamentous fungi." Mycopathologia 155(4): 195-201. <http://hdl.handle.net/2027.42/43273>en_US
dc.identifier.issn0301-486Xen_US
dc.identifier.issn1573-0832en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/43273
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12650595&dopt=citationen_US
dc.description.abstractSurfactant nanoemulsions are water in oil preparations that proved to have a broad spectrum biocidal activity against a variety of microorganisms including Gram-positive and Gram-negative bacteria, spores and enveloped viruses. These preparations are non-toxic to the skin, mucous membrane and gastrointestinal tissues at biocidal concentrations. In this study, 0.1% of the nanoemulsion designated X8W 60 PC has shown fungicidal activity against yeast including Candida albicans and C. tropicalis in 15 minutes. C. tropicalis was more sensitive than C. albicans , which required a longer time or a higher concentration of the nanoemulsion to achieve killing. Neutral to slightly alkaline pH was more effective in killing the yeast cells than acidic pH. Using the minimum inhibitory concentration assay, 0.08% of the nanoemulsion was inhibitory to C. albicans , and parapsilosis and filamentous fungi including Microsporum gypseum , Trichophyton mentagrophytes , Trichophyton rubrum , Aspergillus fumigatus and Fusarium oxysporum .None of the individual ingredients was as effective a fungicidal as the nanoemulsion at equivalent concentration. This shows that the nanoemulsion structure is an important factor in the anti-fungal activity. The X8W 60 PC has great potential as a topical anti-fungal agent and further investigation into the mechanism of fungicidal action is warranted.en_US
dc.format.extent619848 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers; Springer Science+Business Mediaen_US
dc.subject.otherLife Sciencesen_US
dc.subject.otherMedical Microbiologyen_US
dc.subject.otherMicrobial Ecologyen_US
dc.subject.otherMicrobiologyen_US
dc.subject.otherPlant Sciencesen_US
dc.subject.otherNanoemulsionen_US
dc.subject.otherFungicidalen_US
dc.subject.otherTopical Treatmenten_US
dc.subject.otherYeasten_US
dc.subject.otherFilamentous Fungien_US
dc.subject.otherDisinfectanten_US
dc.titleThe fungicidal activity of novel nanoemulsion (X8W 60 PC) against clinically important yeast and filamentous fungien_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, Division of Allergy and Center for Biologic Nanotechnology, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, Division of Allergy and Center for Biologic Nanotechnology, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, Division of Allergy and Center for Biologic Nanotechnology, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, Division of Allergy and Center for Biologic Nanotechnology, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationotherNanoBio Corporation, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid12650595en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/43273/1/11046_2004_Article_5096122.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1023/A:1021129710316en_US
dc.identifier.sourceMycopathologiaen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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