Extrapyramidal Side Effects of Antipsychotic Treatment: Scope of Problem and Impact on Outcome
dc.contributor.author | Jibson, Michael D. | en_US |
dc.contributor.author | Tandon, Rajiv | en_US |
dc.date.accessioned | 2006-09-11T14:09:15Z | |
dc.date.available | 2006-09-11T14:09:15Z | |
dc.date.issued | 2002-06 | en_US |
dc.identifier.citation | Tandon, Rajiv; Jibson, Michael D.; (2002). "Extrapyramidal Side Effects of Antipsychotic Treatment: Scope of Problem and Impact on Outcome." Annals of Clinical Psychiatry 14(2): 123-129. <http://hdl.handle.net/2027.42/44008> | en_US |
dc.identifier.issn | 1040-1237 | en_US |
dc.identifier.issn | 1573-3238 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44008 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12238737&dopt=citation | en_US |
dc.description.abstract | clinicians worked with antipsychotic drugs (conventional or typical) that almost invariably caused extrapyramidal symptoms (EPS) at clinically effective doses. This led to the false impression that all antipsychotics were the same, and that EPS were an unavoidable consequence of effective antipsychotic therapy. EPS adversely impact several aspects of antipsychotic efficacy and tolerability, thereby worsening outcome of afflicted individuals. EPS reduce beneficial effects of antipsychotic treatment on the negative, cognitive, and mood symptom domains, while increasing the risk of tardive dyskinesia and reducing compliance. By definition, the newer generation of “atypical” antipsychotic agents are significantly better than conventional agents with regard to EPS (i.e., they are clinically effective at doses at which they do not cause EPS). Pharmacologically, this difference is expressed in the greater degree of separation between respective dose response curves for antipsychotic and EPS effects observed for “atypical” in contrast to conventional agents. Clinically, this EPS advantage of atypical antipsychotics translates into several important benefits, including better negative symptom efficacy, less dysphoria, less impaired cognition, a lower risk of TD, and better overall outcome. | en_US |
dc.format.extent | 465380 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; American Academy of Clinical Psychiatrists ; Springer Science+Business Media | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Parkinsonism | en_US |
dc.subject.other | Akathisia | en_US |
dc.subject.other | Neurology | en_US |
dc.subject.other | Psychiatry | en_US |
dc.subject.other | Psychopharmacology | en_US |
dc.subject.other | Akinesia | en_US |
dc.subject.other | Dyskinesia | en_US |
dc.subject.other | Extrapyramidal Symptoms | en_US |
dc.subject.other | Antipsychotic | en_US |
dc.subject.other | Neuroleptic | en_US |
dc.subject.other | Treatment | en_US |
dc.title | Extrapyramidal Side Effects of Antipsychotic Treatment: Scope of Problem and Impact on Outcome | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 12238737 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44008/1/10442_2004_Article_377854.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1016811222688 | en_US |
dc.identifier.source | Annals of Clinical Psychiatry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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