Dopamine-β-hydroxylase activity and ethanol-induced sleep time in selectively bred and heterogeneous stock mice
dc.contributor.author | Horowitz, Gary P. | en_US |
dc.contributor.author | Dendel, Peter S. | en_US |
dc.contributor.author | Allan, Andrea M. | en_US |
dc.contributor.author | Major, Leslie F. | en_US |
dc.date.accessioned | 2006-09-11T14:17:39Z | |
dc.date.available | 2006-09-11T14:17:39Z | |
dc.date.issued | 1982-11 | en_US |
dc.identifier.citation | Horowitz, Gary P.; Dendel, Peter S.; Allan, Andrea M.; Major, Leslie F.; (1982). "Dopamine-β-hydroxylase activity and ethanol-induced sleep time in selectively bred and heterogeneous stock mice." Behavior Genetics 12(6): 549-561. <http://hdl.handle.net/2027.42/44105> | en_US |
dc.identifier.issn | 0001-8244 | en_US |
dc.identifier.issn | 1573-3297 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44105 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6305324&dopt=citation | en_US |
dc.description.abstract | Dopamine-β-hydroxylase (DBH), the enzyme responsible for the conversion of dopamine to norepinephrine, was measured in the plasma of two lines of mice selectively bred for differential sensitivity to hypnotic doses of ethanol. Plasma levels of DBH were measured by radioenzymatic assay in long sleep (LS) and short sleep (SS) male and female mice which had no prior exposure to ethanol. LS mice had significantly higher plasma DBH activity than did SS mice, although no significant sex difference was found. Fusaric acid, an inhibitor of both central and peripheral DBH, attenuated sleep time induced by either 3 or 4 g/kg ethanol in mice of a heterogeneous genetic stock. The results of these experiments may further implicate noradrenergic systems in mediating some of the depressed effects of ethanol. | en_US |
dc.format.extent | 798186 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Selective Breeding | en_US |
dc.subject.other | Neurosciences | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Human Genetics | en_US |
dc.subject.other | Evolutionary Biology | en_US |
dc.subject.other | Mice | en_US |
dc.subject.other | Dopamine-β-Hydroxylase | en_US |
dc.subject.other | Ethanol Sensitivity | en_US |
dc.subject.other | Fusaric Acid | en_US |
dc.title | Dopamine-β-hydroxylase activity and ethanol-induced sleep time in selectively bred and heterogeneous stock mice | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Clinical Campus, University Center at Binghamton/Upstate Medical Center, 13901, Binghamton, New York; University of Michigan Medical School, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Clinical Campus, University Center at Binghamton/Upstate Medical Center, 13901, Binghamton, New York | en_US |
dc.contributor.affiliationother | Department of Psychology and Center for Neurobehavioral Sciences, State University of New York at Binghamton, 13901, Binghamton, New York; McNeil Pharmaceuticals, 19477, Spring House, Pennsylvania | en_US |
dc.contributor.affiliationother | Department of Psychology and Center for Neurobehavioral Sciences, State University of New York at Binghamton, 13901, Binghamton, New York | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 6305324 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44105/1/10519_2005_Article_BF01070409.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01070409 | en_US |
dc.identifier.source | Behavior Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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