Individual differences in sensitivity to nicotine: Implications for genetic research on nicotine dependence
dc.contributor.author | Pomerleau, Ovide F. | en_US |
dc.date.accessioned | 2006-09-11T14:18:11Z | |
dc.date.available | 2006-09-11T14:18:11Z | |
dc.date.issued | 1995-03 | en_US |
dc.identifier.citation | Pomerleau, Ovide F.; (1995). "Individual differences in sensitivity to nicotine: Implications for genetic research on nicotine dependence." Behavior Genetics 25(2): 161-177. <http://hdl.handle.net/2027.42/44111> | en_US |
dc.identifier.issn | 0001-8244 | en_US |
dc.identifier.issn | 1573-3297 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44111 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7733857&dopt=citation | en_US |
dc.description.abstract | Recent evidence suggests that cigarette smoking has a heritability index around 53%. While related research on underlying mechanisms also supports the idea that genetic factors contribute to nicotine dependence—as well as to cofactors such as substance use and mood disorders—the nature of the behavioral traits and biological capacity for reinforcement that constitutes vulnerability to nicotine dependence is not well understood. The present review explores the problem of why some people become highly nicotine dependent, others develop a pattern of occasional use, and still others avoid the drug entirely despite extensive exposure and widespread experimentation with tobacco in the population. Recent research—both infrahuman and human—suggests that vulnerability to nicotine dependence is related to high initial sensitivity to nicotine and that the development of tolerance is more rapid and self-administration more extensive in such individuals. Relevant findings from neuroscience and biobehavioral research are reviewed in order to identify variables and methodologies that might improve the reliability and validity of behavioral and molecular genetic studies on cigarette smoking. The integration of research in these areas may lead to new insights in the understanding of nicotine dependence as well as to improved techniques for prevention and treatment. | en_US |
dc.format.extent | 1749442 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Neurosciences | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Human Genetics | en_US |
dc.subject.other | Evolutionary Biology | en_US |
dc.subject.other | Drug Sensitivity | en_US |
dc.subject.other | Dependence | en_US |
dc.subject.other | Tolerance | en_US |
dc.subject.other | Nicotine | en_US |
dc.subject.other | Smoking | en_US |
dc.title | Individual differences in sensitivity to nicotine: Implications for genetic research on nicotine dependence | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Behavioral Medicine Program, Department of Psychiatry, University of Michigan, 475 Market Place, Suite L, 48105, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 7733857 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44111/1/10519_2005_Article_BF02196925.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF02196925 | en_US |
dc.identifier.source | Behavior Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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