Electrophoretic variation in human serum ceruloplasmin: A new genetic polymorphism
dc.contributor.author | Shreffler, Donald C. | en_US |
dc.contributor.author | Brewer, George J. | en_US |
dc.contributor.author | Gall, John C. | en_US |
dc.contributor.author | Honeyman, Merton S. | en_US |
dc.date.accessioned | 2006-09-11T14:18:37Z | |
dc.date.available | 2006-09-11T14:18:37Z | |
dc.date.issued | 1967-09 | en_US |
dc.identifier.citation | Shreffler, D. C.; Brewer, G. J.; Gall, J. C.; Honeyman, M. S.; (1967). "Electrophoretic variation in human serum ceruloplasmin: A new genetic polymorphism." Biochemical Genetics 1(2): 101-115. <http://hdl.handle.net/2027.42/44116> | en_US |
dc.identifier.issn | 0006-2928 | en_US |
dc.identifier.issn | 1573-4927 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44116 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4180112&dopt=citation | en_US |
dc.description.abstract | Through the application of a specific oxidase stain to results of starch gel electrophoresis of human serum, three different electrophoretic forms of ceruloplasmin—denoted CpA (fast), CpB (intermediate), and CpC (slow)—have been defined. The electrophoretic differences are small and were first recognized through a rare variant individual who had only the fast and slow forms. Five phenotypes displaying different combinations of the three electrophoretic forms have been defined in American Negroes; these are called CpA, CpAB, CpB, CpAC, and CpBC. Twin, family, and population studies have yielded evidence indicating that the A and B electrophoretic forms are controlled by a pair of autosomal codominant alleles, designated Cp A and Cp B , and suggesting that the C form may be determined by a third allele, Cp C , at the same locus. The variants constitute a genetic polymorphism in American Negroes, but occur only rarely in Caucasians. | en_US |
dc.format.extent | 776544 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Human Genetics | en_US |
dc.subject.other | Medical Microbiology | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Zoology | en_US |
dc.title | Electrophoretic variation in human serum ceruloplasmin: A new genetic polymorphism | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, Michigan; Department of Medicine (Simpson Memorial Institute), University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, Michigan; Department of Medicine (Simpson Memorial Institute), University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Connecticut State Department of Health, Hartford, Connecticut | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 4180112 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44116/1/10528_2004_Article_BF00486512.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00486512 | en_US |
dc.identifier.source | Biochemical Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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