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Association in Long-Evans hooded rats of red cell 2,3-diphosphoglycerate levels with hemoglobin types

dc.contributor.authorBrewer, George J.en_US
dc.contributor.authorGilman, J. G.en_US
dc.contributor.authorNoble, Nancy A.en_US
dc.contributor.authorCrews, V.en_US
dc.date.accessioned2006-09-11T14:19:50Z
dc.date.available2006-09-11T14:19:50Z
dc.date.issued1978-08en_US
dc.identifier.citationBrewer, G.; Gilman, J.; Noble, N.; Crews, V.; (1978). "Association in Long-Evans hooded rats of red cell 2,3-diphosphoglycerate levels with hemoglobin types." Biochemical Genetics 16 (7-8): 695-707. <http://hdl.handle.net/2027.42/44130>en_US
dc.identifier.issn1573-4927en_US
dc.identifier.issn0006-2928en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/44130
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=728062&dopt=citationen_US
dc.description.abstractTwo sublines of commercially available Long-Evans hooded rats have been developed by genetic selection. These sublines have widely differing levels of erythrocyte 2,3-diphosphoglycerate (DPG) due to different alleles at a single genetic locus. In the present work, it is shown that rats from the commercial population are also polymorphic at a hemoglobin locus, probably involving two alleles of the III β-globin chain locus. Particular hemoglobin types have been found to be strongly associated with certain DPG types, not only in the high-DPG and low-DPG lines but also in the commercial population. Two explanations for this association are considered. One is a single-locus hypothesis, with hemoglobin allelic variation causing DPG variation, and the other is a two-locus hypothesis, with marked linkage disequilibrium.en_US
dc.format.extent721801 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherHemoglobinen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherHuman Geneticsen_US
dc.subject.otherMedical Microbiologyen_US
dc.subject.otherZoologyen_US
dc.subject.otherLong-Evans Hooded Ratsen_US
dc.subject.otherErythrocyte 2,3-diphosphoglycerateen_US
dc.titleAssociation in Long-Evans hooded rats of red cell 2,3-diphosphoglycerate levels with hemoglobin typesen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Human Genetics and Medicine, University of Michigan, 48109, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartments of Human Genetics and Medicine, University of Michigan, 48109, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartments of Human Genetics and Medicine, University of Michigan, 48109, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartments of Human Genetics and Medicine, University of Michigan, 48109, Ann Arbor, Michiganen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid728062en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/44130/1/10528_2004_Article_BF00484727.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF00484727en_US
dc.identifier.sourceBiochemical Geneticsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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