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Fluoride inhibition in patients with atypical dibucaine-resistant plasmacholinesterase

dc.contributor.authorKothary, Sarla P.en_US
dc.contributor.authorFlynn, Kathleen B.en_US
dc.contributor.authorZsigmond, Elemér K.en_US
dc.date.accessioned2006-09-11T14:19:55Z
dc.date.available2006-09-11T14:19:55Z
dc.date.issued1979-12en_US
dc.identifier.citationKothary, Sarla P.; Flynn, Kathleen B.; Zsigmond, Elemér K.; (1979). "Fluoride inhibition in patients with atypical dibucaine-resistant plasmacholinesterase." Biochemical Genetics 17 (11-12): 1169-1172. <http://hdl.handle.net/2027.42/44131>en_US
dc.identifier.issn0006-2928en_US
dc.identifier.issn1573-4927en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/44131
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=540007&dopt=citationen_US
dc.description.abstractThe fluoride numbers (FN) of 144 individuals referred to our laboratory for dibucaine number (DN) determinations because of prolonged apnea following succinylcholine in the probands or relatives were determined by our new method using 2.5×10 −4 M concentration of sodium fluoride at 37 C. Dibucaine-resistant homozygotes and heterozygotes both had lower FN than the normal homozygotes. A linear correlation between DN and FN for all these genotypes was found which is described by the equation FN=0.59DN+32. The correlation coefficient was r=0.94. This equation will help in the correct identification of atypical fluoride resistant genotypes, since these ought to have an observed FN lower by 2 standard deviations than the FN calculated from this equation.en_US
dc.format.extent214582 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherZoologyen_US
dc.subject.otherHuman Geneticsen_US
dc.subject.otherMedical Microbiologyen_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherFN-DN Correlationen_US
dc.subject.otherFluoride-resistant Plasmacholinesterase, Dibucaine-resistant Plasmacholinesteraseen_US
dc.subject.otherBiomedicineen_US
dc.titleFluoride inhibition in patients with atypical dibucaine-resistant plasmacholinesteraseen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan Medical Center, 48109, Ann Arbor, Michiganen_US
dc.contributor.affiliationumUniversity of Michigan Medical Center, 48109, Ann Arbor, Michiganen_US
dc.contributor.affiliationumUniversity of Michigan Medical Center, 48109, Ann Arbor, Michiganen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid540007en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/44131/1/10528_2004_Article_BF00504354.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF00504354en_US
dc.identifier.sourceBiochemical Geneticsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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