Two new ceruloplasmin variants in Negroes—Data on three populations

Abstract

Two new electrophoretic variants in human serum ceruloplasmin are described. The first, called Cp New Haven (CpNH), is determined by an allele at the same autosomal locus which controls the previously described CpA and CpB variants. It migrates with a mobility between CpB and CpC. The variant has been encountered in American as well as Nigerian and Haitian Negroes. The minimal estimate of Cp NH gene frequency in American Negroes is about 0.006. The second variant, named Cp Bridgeport (Cp Bpt), has a mobility between CpA and CpB. It apparently has an extremely low frequency. Similar to CpNH, the Cp Bpt genetic determinant seems to be an autosomal codominant gene. Its relationship to Cp A , Cp C , and Cp NH is, however, unknown. The frequencies of Cp variants in a number of populations are presented.