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Genetic variation in the carbonic anhydrase isozymes of macaque monkeys. II. Inheritance of red cell carbonic anhydrase levels in different carbonic anhydrase I genotypes of the pig-tailed macaque, Macaca nemestrina

dc.contributor.authorMagid, Eriken_US
dc.contributor.authorDeSimone, Josephen_US
dc.contributor.authorTashian, Richard E.en_US
dc.date.accessioned2006-09-11T14:24:14Z
dc.date.available2006-09-11T14:24:14Z
dc.date.issued1973-02en_US
dc.identifier.citationDeSimone, Joseph; Magid, Erik; Tashian, Richard E.; (1973). "Genetic variation in the carbonic anhydrase isozymes of macaque monkeys. II. Inheritance of red cell carbonic anhydrase levels in different carbonic anhydrase I genotypes of the pig-tailed macaque, Macaca nemestrina ." Biochemical Genetics 8(2): 165-174. <http://hdl.handle.net/2027.42/44182>en_US
dc.identifier.issn0006-2928en_US
dc.identifier.issn1573-4927en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/44182
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4632296&dopt=citationen_US
dc.description.abstractThe inheritance of red blood cell levels of carbonic anhydrase isozymes (CA I and CA II) has been studied in different carbonic anhydrase I genotypes of the pig-tailed macaque, Macaca nemestrina . Quantitation of CA I isozymes in a series of animals indicates that the total CA I concentration is the sum of the average effects of each CA I structural allele and that the average effects are independent of the various allelic combinations. The relative average effects were 0.32:0.95:1.0 for the CA I a , CA I b , and CA I c structural genes, respectively. It is also demonstrated that the level of CA II is related to the CA I genotypes. Multiple regression analysis demonstrated that each dose of CA I-deficiency gene present decreased the CA II concentration by approximately 30%, with this decrease in CA II level being solely related to the dose of CA I-deficiency gene and not to the level of CA I. The CA I-deficient animals produce CA I products that are similar to the common CA Ia, CA Ib, CA Ic electrophoretic types. Limited mating data indicate that the CA I components in CA I-deficient animals are inherited codominantly.en_US
dc.format.extent526966 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherHuman Geneticsen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherMedical Microbiologyen_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherZoologyen_US
dc.titleGenetic variation in the carbonic anhydrase isozymes of macaque monkeys. II. Inheritance of red cell carbonic anhydrase levels in different carbonic anhydrase I genotypes of the pig-tailed macaque, Macaca nemestrinaen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan; Department of Clinical Chemistry, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400, Copenhagen NV, Denmarken_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, Michiganen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid4632296en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/44182/1/10528_2004_Article_BF00485544.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF00485544en_US
dc.identifier.sourceBiochemical Geneticsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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