The intratracheal administration of endotoxin: X. Dexamethasone downregulates neutrophil emigration and cytokine expression in vivo
dc.contributor.author | Ulich, Thomas R. | en_US |
dc.contributor.author | Tang, Winson | en_US |
dc.contributor.author | Yin, Songmei | en_US |
dc.contributor.author | Bedoya, Adriana | en_US |
dc.contributor.author | Lim, Young | en_US |
dc.contributor.author | Yi, Eunhee S. | en_US |
dc.contributor.author | Remick, Daniel G. | en_US |
dc.contributor.author | Nadzienko, Christine E. | en_US |
dc.date.accessioned | 2006-09-11T14:55:09Z | |
dc.date.available | 2006-09-11T14:55:09Z | |
dc.date.issued | 1996-04 | en_US |
dc.identifier.citation | Yi, Eunhee S.; Remick, Daniel G.; Lim, Young; Tang, Winson; Nadzienko, Christine E.; Bedoya, Adriana; Yin, Songmei; Ulich, Thomas R.; (1996). "The intratracheal administration of endotoxin: X. Dexamethasone downregulates neutrophil emigration and cytokine expression in vivo." Inflammation 20(2): 165-175. <http://hdl.handle.net/2027.42/44515> | en_US |
dc.identifier.issn | 0360-3997 | en_US |
dc.identifier.issn | 1573-2576 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44515 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8728019&dopt=citation | en_US |
dc.description.abstract | Intratracheal instillation of endotoxin (LPS) causes acute pulmonary inflammation characterized by the accumulation of plasma proteins and leukocytes within the pulmonary airways. The synthetic glucocorticoid dexamethasone 1) inhibits the LPS-initiated vascular leak of plasma proteins into the airspace, 2) inhibits the LPS-initiated emigration of neutrophils and lymphocytes into the airspace in a dose-dependent fashion, and 3) inhibits LPS-initiated mRNA and/or bronchoalveolar lavage protein expression of cytokines (TNF, IL-1 and IL-6) and chemokines (MIP-l α , MIP-2 and MCP-1). In conclusion, dexamethasone inhibits both the vascular and cellular aspects of acute inflammation by downregulation of a broad spectrum of inflammatory cytokines and chemokines. | en_US |
dc.format.extent | 854485 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Internal Medicine | en_US |
dc.subject.other | Rheumatology | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Pathology | en_US |
dc.title | The intratracheal administration of endotoxin: X. Dexamethasone downregulates neutrophil emigration and cytokine expression in vivo | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pathology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan School of Medicine, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Pathology, University of California at San Diego School of Medicine, 92103, San Diego, California | en_US |
dc.contributor.affiliationother | Laboratory of Molecular Immunoregulation Biological Response Modifiers Program, National Cancer Institute, 21702, Frederick, Maryland | en_US |
dc.contributor.affiliationother | Amgen, Inc., 1840 DeHavilland Drive, 91320, Thousand Oaks, California | en_US |
dc.contributor.affiliationother | Department of Pathology, University of California at Irvine School of Medicine, 92717, Irvine, California | en_US |
dc.contributor.affiliationother | Department of Pathology, University of California at San Diego School of Medicine, 92103, San Diego, California | en_US |
dc.contributor.affiliationother | Amgen, Inc., 1840 DeHavilland Drive, 91320, Thousand Oaks, California | en_US |
dc.contributor.affiliationother | Department of Pathology, University of California at San Diego School of Medicine, 92103, San Diego, California; Amgen, Inc., 1840 DeHavilland Drive, 91320, Thousand Oaks, California | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 8728019 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44515/1/10753_2005_Article_BF01487403.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01487403 | en_US |
dc.identifier.source | Inflammation | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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