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Cytokine and Adhesion Molecule Requirements for Lung Injury Induced by Anti-Glomerular Basement Membrane Antibody

dc.contributor.authorMulligan, Michael S.en_US
dc.contributor.authorLentsch, Alex B.en_US
dc.contributor.authorShanley, Thomas P.en_US
dc.contributor.authorMiyasaka, Masayukien_US
dc.contributor.authorJohnson, Kent J.en_US
dc.contributor.authorWard, Peter A.en_US
dc.date.accessioned2006-09-11T14:55:31Z
dc.date.available2006-09-11T14:55:31Z
dc.date.issued1998-08en_US
dc.identifier.citationMulligan, Michael S.; Lentsch, Alex B.; Shanley, Thomas P.; Miyasaka, Masayuki; Johnson, Kent J.; Ward, Peter A.; (1998). "Cytokine and Adhesion Molecule Requirements for Lung Injury Induced by Anti-Glomerular Basement Membrane Antibody." Inflammation 22(4): 403-417. <http://hdl.handle.net/2027.42/44520>en_US
dc.identifier.issn0360-3997en_US
dc.identifier.issn1573-2576en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/44520
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9675611&dopt=citationen_US
dc.description.abstractAcute hemorrhagic lung injury occurs in humans with anti-GBM antibody (Goodpasture's syndrome), however, the mechanism of this injury is still largely unknown. To date, treatment has been confined to steroids and plasmaphoresis. Infusion of anti-GBM antibody into rats caused lung injury with intra-alveolar hemorrhage and intrapulmonary accumulation of neutrophils. Lung injury was dependent on the presence of neutrophils and complement and required both TNFα and IL-1. Experiments employing blocking antibodies to adhesion molecules demonstrated requirements for the β 1 integrin VLA-4, β 2 integrins LFA-1 and Mac-1, and L-selectin. The endothelial cell adhesion molecules, E-selectin and ICAM-1, were also required for the full development of lung injury. Inhibition of TNFα or IL-1 or adhesion molecules reduced both lung injury and tissue neutrophil accumulation. Thus, this study underscores cytokine and adhesion molecule requirements for neutrophil mediated injury in lung and kidney caused by anti-GBM, suggesting potential targets for the treatment of Goodpasture's syndrome in humans.en_US
dc.format.extent1371765 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherRheumatologyen_US
dc.subject.otherMedicine & Public Healthen_US
dc.subject.otherInternal Medicineen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.subject.otherPathologyen_US
dc.titleCytokine and Adhesion Molecule Requirements for Lung Injury Induced by Anti-Glomerular Basement Membrane Antibodyen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPathologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationotherDepartment of Bioregulation, Osaka University Medical School, Japanen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid9675611en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/44520/1/10753_2004_Article_416573.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1023/A:1022372900175en_US
dc.identifier.sourceInflammationen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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