View Item 

Show simple item record

The mTOR/p70 S6K Signal Transduction Pathway Plays a Role in Cardiac Hypertrophy and Influences Expression of Myosin Heavy Chain Genes in vivo

dc.contributor.authorBoluyt, Marvin O.en_US
dc.contributor.authorLi, Zhao Boen_US
dc.contributor.authorLoyd, Amy M.en_US
dc.contributor.authorScalia, Antony F.en_US
dc.contributor.authorCirrincione, Georgina M.en_US
dc.contributor.authorJackson, Rebecca R.en_US
dc.date.accessioned2006-09-11T15:00:10Z
dc.date.available2006-09-11T15:00:10Z
dc.date.issued2004-07en_US
dc.identifier.citationBoluyt, Marvin O.; Li, Zhao Bo; Loyd, Amy M.; Scalia, Antony F.; Cirrincione, Georgina M.; Jackson, Rebecca R.; (2004). "The mTOR/p70 S6K Signal Transduction Pathway Plays a Role in Cardiac Hypertrophy and Influences Expression of Myosin Heavy Chain Genes in vivo." Cardiovascular Drugs and Therapy 18(4): 257-267. <http://hdl.handle.net/2027.42/44579>en_US
dc.identifier.issn0920-3206en_US
dc.identifier.issn1573-7241en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/44579
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15367823&dopt=citationen_US
dc.description.abstractObjective: Rapamycin (R) inhibits p70 S6 kinase (p70 S6K ) activity and hypertrophy of cultured neonatal rat cardiac myocytes. The purpose of the present study was to determine whether rapamycin inhibits left ventricular (L V) hypertrophy in intact rats and whether it alters cardiac gene expression.en_US
dc.format.extent273479 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers; Springer Science+Business Mediaen_US
dc.subject.otherMedicine & Public Healthen_US
dc.subject.otherCardiologyen_US
dc.subject.otherPressure Overloaden_US
dc.subject.otherCardiac Hypertrophyen_US
dc.subject.otherImmunosuppressanten_US
dc.subject.otherMyosin Heavy Chainen_US
dc.subject.otherRapamycinen_US
dc.subject.otherSignal Transductionen_US
dc.subject.otherTranslational Regulationen_US
dc.titleThe mTOR/p70 S6K Signal Transduction Pathway Plays a Role in Cardiac Hypertrophy and Influences Expression of Myosin Heavy Chain Genes in vivoen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumLaboratory of Molecular Kinesiology, The University of Michigan, Ann Arbor, MI, 48109-2214, USAen_US
dc.contributor.affiliationumLaboratory of Molecular Kinesiology, The University of Michigan, Ann Arbor, MI, 48109-2214, USAen_US
dc.contributor.affiliationumLaboratory of Molecular Kinesiology, The University of Michigan, Ann Arbor, MI, 48109-2214, USAen_US
dc.contributor.affiliationumLaboratory of Molecular Kinesiology, The University of Michigan, Ann Arbor, MI, 48109-2214, USAen_US
dc.contributor.affiliationumLaboratory of Molecular Kinesiology, The University of Michigan, Ann Arbor, MI, 48109-2214, USAen_US
dc.contributor.affiliationumLaboratory of Molecular Kinesiology, The University of Michigan, Ann Arbor, MI, 48109-2214, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid15367823en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/44579/1/10557_2004_Article_5277209.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1023/B:CARD.0000041245.61136.56en_US
dc.identifier.sourceCardiovascular Drugs and Therapyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
10557_2004_Article_5277209.pdf
Size:
267.0KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.