Bacteriolysis is inhibited by hydrogen peroxide and by proteases
dc.contributor.author | Ginsburg, Isaac | en_US |
dc.date.accessioned | 2006-09-11T15:26:57Z | |
dc.date.available | 2006-09-11T15:26:57Z | |
dc.date.issued | 1989-11 | en_US |
dc.identifier.citation | Ginsburg, I.; (1989). "Bacteriolysis is inhibited by hydrogen peroxide and by proteases." Agents and Actions 28 (3-4): 238-242. <http://hdl.handle.net/2027.42/44923> | en_US |
dc.identifier.issn | 0065-4299 | en_US |
dc.identifier.issn | 1420-908X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/44923 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2688383&dopt=citation | en_US |
dc.description.abstract | Treatment of Staphylococcus aureus in vitro with cationic agents results in the activation of their autolytic wall enzymes and in the degradation of their cell walls. Exposure of staphylococci either to hydrogen peroxide or the proteinases abolished the autolytic process. This effect was totally reversed by catalase and by proteinase inhibitors, respectively. It is suggested that the failure of neutrophils and macrophages to effectively degrade microbial cell wall components in inflammatory sites might be due to the inactivation of the autolytic wall enzymes of bacteria by hydrogen peroxide and by proteinases generated by the activated leukocytes. This might explain the prolonged chronic inflammatory sequelae seen following infections. | en_US |
dc.format.extent | 450224 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Birkhäuser-Verlag; Birkhäuser Verlag ; Springer Science+Business Media | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Immunology | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Allergology | en_US |
dc.subject.other | Dermatology | en_US |
dc.subject.other | Neurology | en_US |
dc.subject.other | Rheumatology | en_US |
dc.title | Bacteriolysis is inhibited by hydrogen peroxide and by proteases | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Oral Biology, The Hebrew University-Hadassah Faculty of Dental Medicine, Founded by the Alpha Omega Fraternity, P.O.B. 1172, 91010, Jerusalem, Israel; The Department of Pathology, Universityof Michigan, 48109-0602, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 2688383 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/44923/1/11_2005_Article_BF01967409.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01967409 | en_US |
dc.identifier.source | Agents and Actions | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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