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Survival of Mammary Stem Cells in Suspension Culture: Implications for Stem Cell Biology and Neoplasia

dc.contributor.authorDontu, Gabrielaen_US
dc.contributor.authorWicha, Max S.en_US
dc.date.accessioned2006-09-11T15:29:54Z
dc.date.available2006-09-11T15:29:54Z
dc.date.issued2005-01en_US
dc.identifier.citationDontu, Gabriela; Wicha, Max S.; (2005). "Survival of Mammary Stem Cells in Suspension Culture: Implications for Stem Cell Biology and Neoplasia." Journal of Mammary Gland Biology and Neoplasia 10(1): 75-86. <http://hdl.handle.net/2027.42/44964>en_US
dc.identifier.issn1083-3021en_US
dc.identifier.issn1573-7039en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/44964
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15886888&dopt=citationen_US
dc.description.abstractThere is increasing evidence that a variety of neoplasms including breast cancer may result from transformation of normal stem and progenitor cells. In the past, isolation and characterization of mammary stem cells has been limited by the lack of suitable culture systems able to maintain these cells in an undifferentiated state in vitro . We have recently described a culture system in which human mammary stem and progenitor cells are able to survive in suspension and produce spherical colonies composed of both stem and progenitor cells. Recent observation that adult stem cells from other tissues may also retain the capacity for growth under anchorage independent conditions suggests a common underlying mechanism. We propose that this mechanism involves the interaction between the canonical Wnt signal pathway and E-cadherin. The Wnt pathway has been implicated in normal stem cell self-renewal in vivo . Furthermore, there is evidence that deregulation of this pathway in the mammary gland and other organs may play a key role in carcinogenesis. Thus, the development of in vitro suspension culture systems not only provides an important new tool for the study of mammary cell biology, but also may have important implications for understanding key molecular pathways in both normal and neoplastic stem cells.en_US
dc.format.extent594226 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Springer Science + Business Media, Inc.en_US
dc.subject.otherMedicine & Public Healthen_US
dc.subject.otherSelf-renewalen_US
dc.subject.otherCancer Stem Cellsen_US
dc.subject.otherOncologyen_US
dc.subject.otherCancer Researchen_US
dc.subject.otherStem Cellsen_US
dc.subject.otherBreast Canceren_US
dc.subject.otherMammary Gland Developmenten_US
dc.subject.otherWnt Signalingen_US
dc.subject.otherDifferentiationen_US
dc.titleSurvival of Mammary Stem Cells in Suspension Culture: Implications for Stem Cell Biology and Neoplasiaen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, Hematology–Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan; 1500 E Medical Center Dr., 7110 CCGC, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumDepartment of Internal Medicine, Hematology–Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid15886888en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/44964/1/10911_2005_Article_2542.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s10911-005-2542-5en_US
dc.identifier.sourceJournal of Mammary Gland Biology and Neoplasiaen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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