The cytokinetic and cytotoxic effects of ICRF-159 and ICRF-187 in vitro and ICRF-187 in human bone marrow in vivo

Wheeler, Richard H.; Clauw, Daniel J.; Natale, Ronald B.; Ruddon, Raymond W.

1983-12

Citation: Wheeler, Richard H.; Clauw, Daniel J.; Natale, Ronald B.; Ruddon, Raymond W.; (1983). "The cytokinetic and cytotoxic effects of ICRF-159 and ICRF-187 in vitro and ICRF-187 in human bone marrow in vivo ." Investigational New Drugs 1 (4): 283-295. <http://hdl.handle.net/2027.42/45135>

Abstract: The cytotoxic and cytokinetic effects of ICRF-159 and its d-enantiomer ICRF-187 have been examined in vitro . The effects of both agents were identical. Cytotoxicity is dependent on both the drug concentration and the duration of drug exposure. Drug exposure for twice the cell cycle time is necessary for maximum effect. Cytotoxicity is also dependent upon the rate of cell proliferation. A rapidly growing cell population is more sensitive to brief drug exposure than a slowly growing population.

ISSN: 0167-6997, 1573-0646

DOIs: http://dx.doi.org/10.1007/BF00177411

PMID: 6432722

URI: http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6432722&dopt=citation

Handle: http://hdl.handle.net/2027.42/45135

Show full item record