(Na + +K + )-adenosinetriphosphatase in the brain of Shiverer (Shi/Shi) mice
dc.contributor.author | Sheedlo, Harold J. | en_US |
dc.contributor.author | Siegel, George J. | en_US |
dc.contributor.author | Desmond, Timothy J. | en_US |
dc.contributor.author | Ernst, Stephen A. | en_US |
dc.date.accessioned | 2006-09-11T16:01:13Z | |
dc.date.available | 2006-09-11T16:01:13Z | |
dc.date.issued | 1987-12 | en_US |
dc.identifier.citation | Sheedlo, Harold J.; Siegel, George J.; Desmond, Timothy J.; Ernst, Stephen A.; (1987). "(Na + +K + )-adenosinetriphosphatase in the brain of Shiverer (Shi/Shi) mice." Neurochemical Research 12(12): 1081-1086. <http://hdl.handle.net/2027.42/45404> | en_US |
dc.identifier.issn | 0364-3190 | en_US |
dc.identifier.issn | 1573-6903 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/45404 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2831467&dopt=citation | en_US |
dc.description.abstract | The myelin-deficient Shiverer (Shi/Shi) mutant mouse may be a useful model in assessing the dependence of brain (Na + +K + )-ATPase concentration and composition on myelin membrane formation. Brain microsomal membranes from age-matched control (+/+) and Shiverer (Shi/Shi) mice were fractionated by differential centrifugation and sucrose gradient sedimentation. No reduction in (Na + +K + )-ATPase specific activity was measured in whole homogenates, high-and low-speed fractions or gradient fractions from brains of Shi/Shi mice as compared to those of +/+ mice. In addition, sodium dodecylsulfatepolyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting with antisera specific for mouse brain (Na + +K + )-ATPase revealed no significant difference in catalytic subunit composition between fractions of +/+ and Shi/Shi brains. The similar results obtained for both +/+ and myelin-deficient Shi/Shi mice suggest that myelin contributes little to total brain (Na + +K + )-ATPase. | en_US |
dc.format.extent | 883000 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Neurology | en_US |
dc.subject.other | Antibody | en_US |
dc.subject.other | Shiverer | en_US |
dc.subject.other | Neurosciences | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Myelin | en_US |
dc.subject.other | (Na + +K + )-ATPase | en_US |
dc.subject.other | Brain | en_US |
dc.subject.other | Mouse | en_US |
dc.subject.other | Biomedicine | en_US |
dc.title | (Na + +K + )-adenosinetriphosphatase in the brain of Shiverer (Shi/Shi) mice | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Neuroscience Laboratory Building, 1103 East Huron, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Neuroscience Laboratory Building, 1103 East Huron, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Neuroscience Laboratory Building, 1103 East Huron, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Anatomy and Cell Biology, University of Michigan, Neuroscience Laboratory Building, 1103 East Huron, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 2831467 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/45404/1/11064_2004_Article_BF00971708.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00971708 | en_US |
dc.identifier.source | Neurochemical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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