Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish subjects

Collins, Francis S.; Bergman, Richard N.; Watanabe, Richard M.; Buchanan, Thomas A.; Tuomilehto, Jaakko; Lazaridis, K. N.; Scott, Laura J.; Mohlke, Karen L.; Silander, K.; Boehnke, Michael; Conneely, Karen N.; Valle, Timo T.

2004-10

Citation: Conneely, K. N.; Silander, K.; Scott, L. J.; Mohlke, K. L.; Lazaridis, K. N.; Valle, T. T.; Tuomilehto, J.; Bergman, R. N.; Watanabe, R. M.; Buchanan, T. A.; Collins, F. S.; Boehnke, M.; (2004). "Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish subjects." Diabetologia 47 (10): 1782-1788. <http://hdl.handle.net/2027.42/46034>

Abstract: Resistin is a peptide hormone produced by adipocytes that is present at high levels in sera of obese mice and may be involved in glucose homeostasis through regulation of insulin sensitivity. Several studies in humans have found associations between polymorphisms in the resistin gene and obesity, insulin sensitivity and blood pressure. An association between variation in the resistin gene and Type 2 diabetes has been reported in some, but not all studies. The aim of this study was to analyse variants of the resistin gene for association with Type 2 diabetes and related traits in a Finnish sample.

ISSN: 1432-0428, 0012-186X

DOIs: http://dx.doi.org/10.1007/s00125-004-1537-x

PMID: 15517149

URI: http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15517149&dopt=citation

Handle: http://hdl.handle.net/2027.42/46034

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