Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy
dc.contributor.author | Li, F. | en_US |
dc.contributor.author | Szabó, C. | en_US |
dc.contributor.author | Pacher, P. | en_US |
dc.contributor.author | Southan, G. J. | en_US |
dc.contributor.author | Abatan, O. I. | en_US |
dc.contributor.author | Charniauskaya, T. | en_US |
dc.contributor.author | Stevens, Martin J. | en_US |
dc.contributor.author | Obrosova, I. G. | en_US |
dc.date.accessioned | 2006-09-11T17:18:01Z | |
dc.date.available | 2006-09-11T17:18:01Z | |
dc.date.issued | 2004-04 | en_US |
dc.identifier.citation | Li, F.; Szabó, C.; Pacher, P.; Southan, G. J.; Abatan, O. I.; Charniauskaya, T.; Stevens, M. J.; Obrosova, I. G.; (2004). "Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy." Diabetologia 47(4): 710-717. <http://hdl.handle.net/2027.42/46035> | en_US |
dc.identifier.issn | 1432-0428 | en_US |
dc.identifier.issn | 0012-186X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46035 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15298348&dopt=citation | en_US |
dc.description.abstract | Poly(ADP-ribose) polymerase activation depletes NAD + and high-energy phosphates, activates protein kinase C, and affects gene expression in various tissues. This study was designed to characterise the effects of the potent, orally active poly(ADP-ribose) polymerase inhibitor PJ34 in the Wistar rat model of early diabetic neuropathy. | en_US |
dc.format.extent | 270863 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Poly(ADP-ribose) Polymerase | en_US |
dc.subject.other | Peripheral Diabetic Neuropathy | en_US |
dc.subject.other | Energy State | en_US |
dc.subject.other | Nerve Blood Flow | en_US |
dc.subject.other | Medicine | en_US |
dc.subject.other | Motor and Sensory Nerve Conduction | en_US |
dc.subject.other | Oxidative and Nitrosative Stress | en_US |
dc.subject.other | PJ34 | en_US |
dc.subject.other | Rat | en_US |
dc.subject.other | Sorbitol Pathway of Glucose Metabolism | en_US |
dc.subject.other | Streptozotocin-diabetes | en_US |
dc.title | Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Rm 5570, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Rm 5570, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Rm 5570, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Rm 5570, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Rm 5570, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Inotek Pharmaceuticals Corporation, Beverly, Massachusetts, USA | en_US |
dc.contributor.affiliationother | Inotek Pharmaceuticals Corporation, Beverly, Massachusetts, USA | en_US |
dc.contributor.affiliationother | Inotek Pharmaceuticals Corporation, Beverly, Massachusetts, USA; Institute of Human Physiology and Experimental Research, Semmelweis University Medical School, Budapest, Hungary | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 15298348 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46035/1/125_2004_Article_1356.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s00125-004-1356-0 | en_US |
dc.identifier.source | Diabetologia | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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