The IA-2 interactome

Notkins, A. L.; Cai, T.; Hu, Y. F.; Zhang, H. L.; Harashima, S.

2005-12

Citation: Hu, Y. F.; Zhang, H. L.; Cai, T.; Harashima, S.; Notkins, A. L.; (2005). "The IA-2 interactome." Diabetologia 48 (12): 2576-2581. <http://hdl.handle.net/2027.42/46036>

Abstract: Islet antigen-2 (IA-2), a major autoantigen in type 1 diabetes, is an enzymatically inactive member of the transmembrane protein tyrosine phosphatase (PTP) family. IA-2 is located in dense-core secretory vesicles and is involved in the regulation of insulin secretion. The present experiments were initiated to identify those proteins that interact with IA-2 (i.e. the IA-2 interactome) as a first step towards elucidating the mechanism(s) by which IA-2 influences insulin secretion and serves as an autoantigen.

ISSN: 0012-186X, 1432-0428

DOIs: http://dx.doi.org/10.1007/s00125-005-0037-y

PMID: 16273344

URI: http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16273344&dopt=citation

Handle: http://hdl.handle.net/2027.42/46036

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