TRH attenuates scopolamine-induced memory impairment in humans
dc.contributor.author | Cohen, Martin Robert. | en_US |
dc.contributor.author | Weingartner, Herbert J. | en_US |
dc.contributor.author | Sunderland, Trey | en_US |
dc.contributor.author | Lawlor, Brian A. | en_US |
dc.contributor.author | Cohen, Robert M. | en_US |
dc.contributor.author | Molchan, Susan E. | en_US |
dc.contributor.author | Mellow, Alan M. | en_US |
dc.date.accessioned | 2006-09-11T17:39:02Z | |
dc.date.available | 2006-09-11T17:39:02Z | |
dc.date.issued | 1990-03 | en_US |
dc.identifier.citation | Molchan, Susan E.; Mellow, Alan M.; Lawlor, Brian A.; Weingartner, Herbert J.; Cohen, Robert M.; Cohen, Martin R.; Sunderland, Trey; (1990). "TRH attenuates scopolamine-induced memory impairment in humans." Psychopharmacology 101(1): 84-89. <http://hdl.handle.net/2027.42/46332> | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.issn | 1432-2072 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46332 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2104988&dopt=citation | en_US |
dc.description.abstract | The brain tripeptide thyrotropin-releasing hormone (TRH) has been demonstrated to facilitate cholinergic neurotransmission. To test its interaction with the cholinergic system in humans, high-dose TRH (0.5 mg/kg) or placebo was administered intravenously (IV) to normal controls pretreated with scopolamine (0.5–0.75 mg IV), a centrally active muscarinic antagonist, which has been used to model aspects of the memory impairment of normal aging and of dementia. Compared to placebo, TRH markedly attenuated scopolamine-induced impairment of some measures of memory, most notably on a selective reminding task. This cognitive study is the first in humans to suggest a neuromodulatory effect of a peptide on the cholinergic system, and suggests a facilitatory role for TRH in human memory processes. | en_US |
dc.format.extent | 957712 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Neuropeptide | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Psychiatry | en_US |
dc.subject.other | Memory | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Thyrotropin-releasing Hormone (TRH) | en_US |
dc.subject.other | Scopolamine | en_US |
dc.title | TRH attenuates scopolamine-induced memory impairment in humans | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychiatry, University of Michigan Medical Center, 1103 East Huron, 48104, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Psychology, George Washington University, 2125 G Street, N.W., 20036, Washington, DC, USA | en_US |
dc.contributor.affiliationother | Unit on Geriatric Psychopharmacology, Section on Clinical Neuropharmacology, Laboratory of Clinical Science, National Institute of Mental Health, 9000 Rockville Pike, 20892, Bethesda, MD, USA; National Institute of Mental Health, NIH Clinical Center, Building 10, Room 3D41, 9000 Rockville Pike, 20892, Bethesda, MD, USA | en_US |
dc.contributor.affiliationother | Unit on Geriatric Psychopharmacology, Section on Clinical Neuropharmacology, Laboratory of Clinical Science, National Institute of Mental Health, 9000 Rockville Pike, 20892, Bethesda, MD, USA | en_US |
dc.contributor.affiliationother | Section on Clinical Brain Imaging, Laboratory of Cerebral Metabolism, National Institute of Mental Health, 9000 Rockville Pike, 20892, Bethesda, MD, USA | en_US |
dc.contributor.affiliationother | Ensor Research Laboratory, William S. Hall Psychiatric Institute, University of South Carolina School of Medicine, P.O. Box 202, 29202, Columbia, SC, USA | en_US |
dc.contributor.affiliationother | Unit on Geriatric Psychopharmacology, Section on Clinical Neuropharmacology, Laboratory of Clinical Science, National Institute of Mental Health, 9000 Rockville Pike, 20892, Bethesda, MD, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 2104988 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46332/1/213_2005_Article_BF02245795.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF02245795 | en_US |
dc.identifier.source | Psychopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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