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Inhibition of phenylethanolamine-N-methyltransferase and brain-stimulated reward

dc.contributor.authorCarroll, Bernard J.en_US
dc.contributor.authorKatz, Richard J.en_US
dc.date.accessioned2006-09-11T17:44:20Z
dc.date.available2006-09-11T17:44:20Z
dc.date.issued1978-01en_US
dc.identifier.citationKatz, R. J.; Carroll, B. J.; (1978). "Inhibition of phenylethanolamine-N-methyltransferase and brain-stimulated reward." Psychopharmacology 57(1): 39-42. <http://hdl.handle.net/2027.42/46401>en_US
dc.identifier.issn0033-3158en_US
dc.identifier.issn1432-2072en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/46401
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=96467&dopt=citationen_US
dc.description.abstractThree centrally active inhibitors of phenylethanolamine-N-methyl transferase (PNMT; E.C.2.1.1.28), the terminal enzyme for epinephrine biosynthesis in the brain, produced dose-related decreases in rates of responding for rewarding brain stimulation in adult male rats. Decreases occurred at dosages that did not produce measurable neurologic impairment. This suggests a possible role for central epinephrine-containing neurons in the maintenance of reward-mediated behaviors.en_US
dc.format.extent347520 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlagen_US
dc.subject.otherPNMTen_US
dc.subject.otherBrain Stimulationen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.subject.otherRewarden_US
dc.subject.otherBiomedicineen_US
dc.subject.otherPsychiatryen_US
dc.subject.otherEpinephrineen_US
dc.titleInhibition of phenylethanolamine-N-methyltransferase and brain-stimulated rewarden_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMental Health Research Institute, Department of Psychiatry, University of Michigan Medical Center, 48109, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumMental Health Research Institute, Department of Psychiatry, University of Michigan Medical Center, 48109, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid96467en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/46401/1/213_2004_Article_BF00426955.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF00426955en_US
dc.identifier.sourcePsychopharmacologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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