Comparison of opioid agonists in maintaining responding and in suppressing morphine withdrawal in rhesus monkeys
dc.contributor.author | Young, Alice M. | en_US |
dc.contributor.author | Swain, Henry H. | en_US |
dc.contributor.author | Woods, James H. | en_US |
dc.date.accessioned | 2006-09-11T17:45:57Z | |
dc.date.available | 2006-09-11T17:45:57Z | |
dc.date.issued | 1981-09 | en_US |
dc.identifier.citation | Young, Alice M.; Swain, Henry H.; Woods, James H.; (1981). "Comparison of opioid agonists in maintaining responding and in suppressing morphine withdrawal in rhesus monkeys." Psychopharmacology 74(4): 329-335. <http://hdl.handle.net/2027.42/46424> | en_US |
dc.identifier.issn | 1432-2072 | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46424 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6794076&dopt=citation | en_US |
dc.description.abstract | Sixteen opioid agonists were studied for their capacity both to maintain responding previously reinforced by codeine and to suppress the withdrawal syndrome induced by morphine deprivation in rhesus monkeys. All compounds, which included examples from each of the major chemical families of opioids, maintained responding at rates above those maintained by saline. There were differences among the compounds in the maximal response rates maintained, and large differences in their potencies in maintaining responding. In morphine-dependent monkeys, the abstinence signs that developed 14 h after the last morphine dose were suppressed completely by all of the compounds except codeine. There was a strong positive correlation ( r =0.92) between the potency of a compound in maintaining drug-reinforced responding and the potency of the compound in suppressing the morphine withdrawal syndrome. | en_US |
dc.format.extent | 856356 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Heroin | en_US |
dc.subject.other | Drug Selfadministration | en_US |
dc.subject.other | Ketobemidone | en_US |
dc.subject.other | Fentanyl | en_US |
dc.subject.other | Morphine | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Azidomorphine | en_US |
dc.subject.other | Drug-reinforced Behavior | en_US |
dc.subject.other | Methadone | en_US |
dc.subject.other | Rhesus Monkeys | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Psychiatry | en_US |
dc.subject.other | Codeine | en_US |
dc.subject.other | Levorphanol | en_US |
dc.subject.other | Meperidine | en_US |
dc.subject.other | Propoxyphene | en_US |
dc.subject.other | Opioid Agonists | en_US |
dc.subject.other | Opioid Dependence | en_US |
dc.subject.other | Morphine Withdrawal Syndrome | en_US |
dc.title | Comparison of opioid agonists in maintaining responding and in suppressing morphine withdrawal in rhesus monkeys | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, Michigan, USA; Department of Psychology, Wayne State University, 767 Mackenzie Hall, 48202, Detroit, MI, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 6794076 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46424/1/213_2004_Article_BF00432741.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00432741 | en_US |
dc.identifier.source | Psychopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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