Mecamylamine pretreatment increases subsequent nicotine self-administration as indicated by changes in plasma nicotine level
dc.contributor.author | Majchrzak, Mark J. | en_US |
dc.contributor.author | Pomerleau, Cynthia S. | en_US |
dc.contributor.author | Pomerleau, Ovide F. | en_US |
dc.date.accessioned | 2006-09-11T17:47:31Z | |
dc.date.available | 2006-09-11T17:47:31Z | |
dc.date.issued | 1987-09 | en_US |
dc.identifier.citation | Pomerleau, C. S.; Pomerleau, O. F.; Majchrzak, M. J.; (1987). "Mecamylamine pretreatment increases subsequent nicotine self-administration as indicated by changes in plasma nicotine level." Psychopharmacology 91(3): 391-393. <http://hdl.handle.net/2027.42/46446> | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.issn | 1432-2072 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46446 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3104964&dopt=citation | en_US |
dc.description.abstract | Acute administration of mecamylamine, a centrally active nicotinic cholinergic agonist, has been shown to increase amount of smoking as indicated by smoking topography (e.g., puff rate, puff duration), expired carbon monoxide changes, and other inferential measures. In the present study, subjects showed significantly greater increases in plasma nicotine following smoking of two high-nicotine research cigarettes when pretreated with mecamylamine than when pretreated with placebo, even though no significant differences in puff volume or puff number were detected. Interestingly, none of our subjects reported nausea, although some achieved plasma nicotine levels at which nausea would typically be expected. We attribute the observed increases in nicotine intake to compensatory behavior designed to overcome mecamylamine's blocking effects. | en_US |
dc.format.extent | 333545 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Mecamylamine | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Psychiatry | en_US |
dc.subject.other | Self-administration | en_US |
dc.subject.other | Cigarette Smoking | en_US |
dc.subject.other | Plasma Nicotine | en_US |
dc.title | Mecamylamine pretreatment increases subsequent nicotine self-administration as indicated by changes in plasma nicotine level | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Behavioral Medicine Program, Department of Psychiatry, University of Michigan, 48105, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Behavioral Medicine Program, Department of Psychiatry, University of Michigan, 48105, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Behavioral Medicine Program, Department of Psychiatry, University of Michigan, 48105, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 3104964 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46446/1/213_2004_Article_BF00518198.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00518198 | en_US |
dc.identifier.source | Psychopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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