Repeated apomorphine administration alters dopamine D1 and D2 receptor densities in pigeon basal telencephalon
dc.contributor.author | Košťál, Ľubor | en_US |
dc.contributor.author | Delius, Juan D. | en_US |
dc.contributor.author | Výboh, Pavel | en_US |
dc.contributor.author | Acerbo, Martin J. | en_US |
dc.contributor.author | Kubíková, Ľubica | en_US |
dc.date.accessioned | 2006-09-11T17:54:28Z | |
dc.date.available | 2006-09-11T17:54:28Z | |
dc.date.issued | 2005-01 | en_US |
dc.identifier.citation | Acerbo, Martin J.; Výboh, Pavel; Košťál, Ľubor; Kubíková, Ľubica; Delius, Juan D.; (2005). "Repeated apomorphine administration alters dopamine D1 and D2 receptor densities in pigeon basal telencephalon." Experimental Brain Research 160(4): 533-537. <http://hdl.handle.net/2027.42/46541> | en_US |
dc.identifier.issn | 1432-1106 | en_US |
dc.identifier.issn | 0014-4819 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46541 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15599724&dopt=citation | en_US |
dc.description.abstract | When pigeons are repeatedly administered a dose of apomorphine they show an increasing behavioral response, much as rodents do. In birds this expresses itself in an augmented pecking response. This sensitization is assumed to be largely due to a conditioning process. Here we present evidence that sensitization is accompanied by an alteration of the D 1 to D 2 dopamine receptor densities. An experimental group of pigeons was repeatedly injected with apomorphine, and a control group with saline. The basal forebrain tissue, known to be rich in dopamine receptors, was subjected to binding assays using tritiated specific D 1 and D 2 dopamine receptor antagonists. There was a trend towards an increase in D 1 and a significant decrease in D 2 receptor densities in apomorphine-treated birds compared to the saline-treated controls. We conclude that extended apomorphine treatment modifies the D 1 dopamine receptor density in the opposite manner to the D 2 dopamine receptor density. | en_US |
dc.format.extent | 107452 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Apomorphine | en_US |
dc.subject.other | Pigeons | en_US |
dc.subject.other | Dopamine Receptors | en_US |
dc.subject.other | Binding Assay | en_US |
dc.subject.other | LifeSciences | en_US |
dc.subject.other | Sensitization | en_US |
dc.title | Repeated apomorphine administration alters dopamine D1 and D2 receptor densities in pigeon basal telencephalon | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Experimental Psychology, University of Konstanz, 78457, Konstanz, Germany; Biopsychology Program, Department of Psychology, University of Michigan, Ann Arbor, MI, 48109-1109, USA | en_US |
dc.contributor.affiliationother | Institute of Animal Biochemistry and Genetics, Slovak Academy of Sciences, 90028, Ivanka pri Dunaji, Slovakia | en_US |
dc.contributor.affiliationother | Institute of Animal Biochemistry and Genetics, Slovak Academy of Sciences, 90028, Ivanka pri Dunaji, Slovakia | en_US |
dc.contributor.affiliationother | Institute of Animal Biochemistry and Genetics, Slovak Academy of Sciences, 90028, Ivanka pri Dunaji, Slovakia | en_US |
dc.contributor.affiliationother | Experimental Psychology, University of Konstanz, 78457, Konstanz, Germany | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 15599724 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46541/1/221_2004_Article_2158.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s00221-004-2158-9 | en_US |
dc.identifier.source | Experimental Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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