Circadian rhythm of urinary pH in man with and without chronic antacid administration
dc.contributor.author | MacKichan, J. | en_US |
dc.contributor.author | Wagner, John G. | en_US |
dc.contributor.author | Weidler, Donald J. | en_US |
dc.contributor.author | Ayres, James W. | en_US |
dc.date.accessioned | 2006-09-11T18:01:19Z | |
dc.date.available | 2006-09-11T18:01:19Z | |
dc.date.issued | 1977-11 | en_US |
dc.identifier.citation | Ayres, J. W.; Weidler, D. J.; MacKichan, J.; Wagner, J. G.; (1977). "Circadian rhythm of urinary pH in man with and without chronic antacid administration." European Journal of Clinical Pharmacology 12(6): 415-420. <http://hdl.handle.net/2027.42/46636> | en_US |
dc.identifier.issn | 0031-6970 | en_US |
dc.identifier.issn | 1432-1041 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46636 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=23296&dopt=citation | en_US |
dc.description.abstract | In normal human volunteers, when urinary pH was plotted versus time, the circadian sine-wave type curve was not altered by chronic administration of a commercially available suspension containing a mixture of magnesium and aluminum hydroxides, although the antacid perturbed the entire curve in a more alkaline direction. A single dose of the antacid had little effect on urinary pH. There was a highly significant linear relationship between the change in hydrogen ion concentration during chronic antacid treatment and the initial control urinary hydrogen ion concentration, but there was no significant correlation between change in urinary pH and initial control urinary pH as has been previously reported. The above results were based on the evaluation of the hydrogen ion concentrations of 1562 separate urine samples collected from 24 normal subjects in a three treatment crossover study. It is recommended that: (1) research studies involving drug-drug interactions with antacids be designed to consider the effect of the antacid on the circadian rhythm of urinary pH, and (2) pH values not be averaged as commonly reported in the literature, but rather the pH values be converted to hydrogen ion concentrations before statistical analysis. | en_US |
dc.format.extent | 779145 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Statistical Analysis | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Circadian Urinary PH | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Chronic Antacid | en_US |
dc.title | Circadian rhythm of urinary pH in man with and without chronic antacid administration | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, Ann Arbor, Michigan, USA; School of Pharmacy, Oregon State University, 97331, Corvallis, Oregon, USA | en_US |
dc.contributor.affiliationum | College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 23296 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46636/1/228_2004_Article_BF00561060.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00561060 | en_US |
dc.identifier.source | European Journal of Clinical Pharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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