Polymorphism in a T-cell receptor variable gene is associated with susceptibility to a juvenile rheumatoid arthritis subset
dc.contributor.author | Kerckhove, Catherine | en_US |
dc.contributor.author | Luyrink, Lorie | en_US |
dc.contributor.author | Maksymowych, Walter P. | en_US |
dc.contributor.author | Gabriel, Christos A. | en_US |
dc.contributor.author | Leiden, Jeffrey M. | en_US |
dc.contributor.author | Elma, Maruja | en_US |
dc.contributor.author | Lovell, Daniel J. | en_US |
dc.contributor.author | Melin-Aldana, Hector | en_US |
dc.contributor.author | Choi, Edmund | en_US |
dc.contributor.author | Glass, David N. | en_US |
dc.date.accessioned | 2006-09-11T18:09:32Z | |
dc.date.available | 2006-09-11T18:09:32Z | |
dc.date.issued | 1992-03 | en_US |
dc.identifier.citation | Maksymowych, Walter P.; Gabriel, Christos A.; Luyrink, Lorie; Melin-Aldana, Hector; Elma, Maruja; Lovell, Daniel J.; Kerckhove, Catherine; Leiden, Jeffrey; Choi, Edmund; Glass, David N.; (1992). "Polymorphism in a T-cell receptor variable gene is associated with susceptibility to a juvenile rheumatoid arthritis subset." Immunogenetics 35(4): 257-262. <http://hdl.handle.net/2027.42/46750> | en_US |
dc.identifier.issn | 0093-7711 | en_US |
dc.identifier.issn | 1432-1211 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46750 | |
dc.description.abstract | This report demonstrates a T-cell receptor (Tcr) restriction fragment length polymorphism, defined by a Tcrb-V6.1 gene probe and Bgl II restriction enzyme, to be absolutely correlated with allelic variation in the coding sequence of a Tcrb-V6.1 gene. A pair of non-conservative amino acid substitutions distinguish the Tcrb-V6.1 allelic variants. An association of this Tcrb-V6.1 gene allelic variant with one form of juvenile rheumatoid arthritis (JRA) was established in a cohort of 126 patients. The association was observed in patients possessing the HLA-DQA1*0101 gene. Among HLA-DQA*0101 individuals, 19 of 26 patients (73.1%) carried one particular Tcrb-V6.1 gene allele as opposed to 11 of 33 controls (33%; p<0.005). Haplotypes carrying this HLA gene have previously been shown to confer increased risk for progression of arthritis in JRA. This demonstration of a disease-associated Tcrb-V gene allelic variant has not, to our knowledge, been previously reported and supports the contribution of polymorphism in the Tcr variable region genomic repertoire to human autoimmune disease. | en_US |
dc.format.extent | 568988 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Allergology | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Immunology | en_US |
dc.subject.other | Cell Biology | en_US |
dc.title | Polymorphism in a T-cell receptor variable gene is associated with susceptibility to a juvenile rheumatoid arthritis subset | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine and Microbiology/Immunology, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, College of Medicine, University of Cincinnati, 45229, OH, USA; Special Treatment Center for Juvenile Arthritis, Children's Hospital Medical Center, Elland and Bethesda Avenues, Pav 1–129, 45229-2899, Cincinnati, OH, USA | en_US |
dc.contributor.affiliationother | Department of Molecular Genetics, Biochemistry and Microbiology, College of Medicine, University of Cincinnati, 45229, OH, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, College of Medicine, University of Cincinnati, 45229, OH, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, College of Medicine, University of Cincinnati, 45229, OH, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, College of Medicine, University of Cincinnati, 45229, OH, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, College of Medicine, University of Cincinnati, 45229, OH, USA | en_US |
dc.contributor.affiliationother | Department of Molecular Genetics, Biochemistry and Microbiology, College of Medicine, University of Cincinnati, 45229, OH, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, College of Medicine, University of Cincinnati, 45229, OH, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, College of Medicine, University of Cincinnati, 45229, OH, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 1347283 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46750/1/251_2004_Article_BF00166831.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00166831 | en_US |
dc.identifier.source | Immunogenetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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