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H-2 and Background influences on tissue grafts across the H-Y barrier

dc.contributor.authorBeals, Theodore F.en_US
dc.contributor.authorSchultz, Jane S.en_US
dc.contributor.authorDeMott-Friberg, Robertaen_US
dc.date.accessioned2006-09-11T18:09:53Z
dc.date.available2006-09-11T18:09:53Z
dc.date.issued1979-12en_US
dc.identifier.citationDeMott-Friberg, Roberta; Beals, Theodore F.; Schultz, Jane S.; (1979). " H-2 and Background influences on tissue grafts across the H-Y barrier." Immunogenetics 9(1): 369-381. <http://hdl.handle.net/2027.42/46755>en_US
dc.identifier.issn1432-1211en_US
dc.identifier.issn0093-7711en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/46755
dc.description.abstractMale liver was grafted to kidney beds in syngeneic female mice. Relative influences of H-2 haplotype, genetic background or interaction of H-2 haplotype with genetic background on anti-H-Y response were evaluated using 27 inbred strains carrying eight H-2 haplotypes of independent origin and three naturally occurring recombinants. Females of H-2 b haplotype acutely rejected the male graft as is reported for other tissue graft systems. An H-2 haplotype influence was found for all haplotypes studied, with a greater variation of immunologic response revealed by histological analysis of liver grafts than is demonstrated by skin grafts. Strains carrying H-2 k , H-2 j and H-2 p haplotypes expressed the greatest range of immunological variability with responses ranging from graft proliferation to graft rejection. Strains carrying the H-2 d haplotype had the most consistent responses with little reaction to the graft. The strong immune response by SJL/J ( H-2 s ) female mice to the H-Y antigen is not typical of other H-2 s strains, but is compatible with the reported hyperresponsiveness of this strain to alloantigens.en_US
dc.format.extent1155169 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlag; Springer-Verlag New York Inc.en_US
dc.subject.otherCell Biologyen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherImmunologyen_US
dc.subject.otherAllergologyen_US
dc.titleH-2 and Background influences on tissue grafts across the H-Y barrieren_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumVeterans Administration Medical Center, 48105, Ann Arbor, Michigan; Departments of Genetics and Pathology, University of Michigan, 48109, Ann Arbor, Michiganen_US
dc.contributor.affiliationumVeterans Administration Medical Center, 48105, Ann Arbor, Michigan; Departments of Genetics and Pathology, University of Michigan, 48109, Ann Arbor, Michiganen_US
dc.contributor.affiliationumVeterans Administration Medical Center, 48105, Ann Arbor, Michigan; Departments of Genetics and Pathology, University of Michigan, 48109, Ann Arbor, Michiganen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/46755/1/251_2005_Article_BF01570432.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF01570432en_US
dc.identifier.sourceImmunogeneticsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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