Insertional mutation of the hairless locus on mouse Chromosome 14
dc.contributor.author | Jones, Julie M. | en_US |
dc.contributor.author | Keller, Scott A. | en_US |
dc.contributor.author | Elder, James T. | en_US |
dc.contributor.author | Simin, Karl | en_US |
dc.contributor.author | Meisler, Miriam H. | en_US |
dc.date.accessioned | 2006-09-11T18:28:34Z | |
dc.date.available | 2006-09-11T18:28:34Z | |
dc.date.issued | 1993-11 | en_US |
dc.identifier.citation | Jones, Julie M.; Elder, James T.; Simin, Karl; Keller, Scott A.; Meisler, Miriam H.; (1993). "Insertional mutation of the hairless locus on mouse Chromosome 14." Mammalian Genome 4(11): 639-643. <http://hdl.handle.net/2027.42/47000> | en_US |
dc.identifier.issn | 0938-8990 | en_US |
dc.identifier.issn | 1432-1777 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47000 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8281013&dopt=citation | en_US |
dc.description.abstract | Crosses between heterozygous transgenic mice from line 5053 produced offspring with progressive irreversible hair loss beginning at day 10. With increasing age, the skin of these animals became thicker and plicated in appearance. Histological analysis revealed the complete absence of normal hair follicles and numerous intradermic cystic structures, which enlarged with time and became filled with keratinaceous material. Test crosses demonstrated that the affected animals are homozygous for the transgene insertion. The clinicla and histological phenotype of the new mutant closely resembles that of the rhino allele at the hairless locus on Chromosome (Chr) 14. Complementation tests and linkage analysis indicate that the transgene has interrupted the hairless locus. It has been demonstrated previously that mutation at the hr locus is accompanied by a variety of immune deficiencies. Many of the older affected transgenic mice developed an impetigo-like skin eruption which responded to antibiotic ointment and which may reflect impaired immune function. The transgenic allele, hr TgN5053Mm , will be useful for identification of the transcription unit of the hairless locus. | en_US |
dc.format.extent | 1273191 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Anatomy | en_US |
dc.subject.other | Cell Biology | en_US |
dc.subject.other | Zoology | en_US |
dc.title | Insertional mutation of the hairless locus on mouse Chromosome 14 | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, 48109, Ann Arbor, Michigan, USA; Department of Radiation Oncology, University of Michigan, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Dermatology, University of Michigan, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 8281013 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47000/1/335_2004_Article_BF00360900.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00360900 | en_US |
dc.identifier.source | Mammalian Genome | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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