Ionic lanthanum passage across cerebral endothelium exposed to hyperosmotic arabinose
dc.contributor.author | Goping, G. | en_US |
dc.contributor.author | Dorovini-zis, Katerina | en_US |
dc.contributor.author | Rapoport, S. | en_US |
dc.contributor.author | Brightman, M. | en_US |
dc.contributor.author | Sato, M. | en_US |
dc.date.accessioned | 2006-09-11T18:44:07Z | |
dc.date.available | 2006-09-11T18:44:07Z | |
dc.date.issued | 1983-03 | en_US |
dc.identifier.citation | Dorovini-Zis, K.; Sato, M.; Goping, G.; Rapoport, S.; Brightman, M.; (1983). "Ionic lanthanum passage across cerebral endothelium exposed to hyperosmotic arabinose." Acta Neuropathologica 60 (1-2): 49-60. <http://hdl.handle.net/2027.42/47227> | en_US |
dc.identifier.issn | 1432-0533 | en_US |
dc.identifier.issn | 0001-6322 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47227 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6880622&dopt=citation | en_US |
dc.description.abstract | Hyperosmotic media infused into the cerebral circulation open the blood-brain barrier to protein and colloid. The mechanism whereby such substances cross the affected vessels is still disputed. We describe here the transendothelial route taken by ionic lanthanum (La 3+ ), a small electron-dense tracer which, unlike colloidal lanthanum, can be administered to the living animal. In adult rats, 2.9 ml of hyperosmotic (1.4 M) arabinose was infused into the internal carotid artery as a 30-s bolus, followed by 5 mM LaCl 3 . To find the extravasated La 3+ , which is invisible by light microscopy, horseradish peroxidase (HRP) was injected simultaneously into the femoral vein. The hyperosmotic treatment resulted in exudation of both HRP and La 3+ primarily around cerebral arterioles. The La 3+ crossed arterioles through successive tight junctions between endothelial cells. Although the tight junctions were not discernibly opened, they must have become permeable because the extracellular pools between successive tight junctions were penetrated by the La 3+ . These pools are normally inaccessible to La 3+ . Luminal and abluminal pits and cytoplasmic vesicles, some of them containing La 3+ , formed intraendothelial clusters. Their role, if any, in the transfer of ion remains remains uncertain. | en_US |
dc.format.extent | 4932435 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag GmbH & Co. KG | en_US |
dc.subject.other | Tight Junctions | en_US |
dc.subject.other | Ionic Lanthanum | en_US |
dc.subject.other | Pathology | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Blood-brain Barrier | en_US |
dc.title | Ionic lanthanum passage across cerebral endothelium exposed to hyperosmotic arabinose | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pathology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Dept. of Pathology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Laboratory of Neuropathology and Neuroanatomical Sciences, NINCDS National Institutes of Health, Bldg. 36, Rm. 3B26, 20205, Bethesda, MD, USA | en_US |
dc.contributor.affiliationother | Laboratory of Neurosciences, National Institute of Aging, 21224, Baltimore, MD, USA | en_US |
dc.contributor.affiliationother | Health Administration Center, Kyoto University, Kyoto, Japan | en_US |
dc.contributor.affiliationother | Laboratory of Neuropathology and Neuroanatomical Sciences, NINCDS National Institutes of Health, Bldg. 36, Rm. 3B26, 20205, Bethesda, MD, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 6880622 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47227/1/401_2004_Article_BF00685347.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00685347 | en_US |
dc.identifier.source | Acta Neuropathologica | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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