Pathogenesis of pili annulati
dc.contributor.author | Hashimoto, K. | en_US |
dc.contributor.author | Sakamoto, F. | en_US |
dc.contributor.author | Voorhees, John J. | en_US |
dc.contributor.author | Ito, M. | en_US |
dc.contributor.author | Sato, Y. | en_US |
dc.date.accessioned | 2006-09-11T18:45:04Z | |
dc.date.available | 2006-09-11T18:45:04Z | |
dc.date.issued | 1988-07 | en_US |
dc.identifier.citation | Ito, M.; Hashimoto, K.; Sakamoto, F.; Sato, Y.; Voorhees, J. J.; (1988). "Pathogenesis of pili annulati." Archives of Dermatological Research 280(5): 308-318. <http://hdl.handle.net/2027.42/47241> | en_US |
dc.identifier.issn | 1432-069X | en_US |
dc.identifier.issn | 0340-3696 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47241 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2460036&dopt=citation | en_US |
dc.description.abstract | Plucked scalp hairs and hair roots of pili annulati were examined to understand their pathogenesis. Stereoscopic examinations of hairs in transmitted light and/or reflected light and light microscopic surveys of the cross-sections of hairs confirmed that the cortical empty spaces appeared to be responsible to the unique dotted shiny appearance of the hairs seen by the unaided eyes under a refracted light. By transmission electron microscope, small vacuoles and dense bodies were observed in the cytoplasm of the differentiating cortical cells; subsequently, with increasing number of tonofilaments, an uneven distribution of free ribosomes occurred and abnormal spaces containing fine granular substances were formed in the cytoplasm of the cortical cells. Occasionally, extremely large cortical trichohyaline granules were found. In the keratinized hair, irregular empty spaces were present in the cortex of the abnormal hair segments. Histochemically, the keratinized cortex of the affected hairs always had more residual SH groups than the controls. Pili annulati may be a disorder of protein metabolism involving a partial dysfunction of cytoplasmic ribosomes, resulting in a lack of cortical keratin formation. | en_US |
dc.format.extent | 6618349 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Ultrastructure | en_US |
dc.subject.other | Pili Annulati | en_US |
dc.subject.other | Dermatology | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Protein Metabolism | en_US |
dc.subject.other | Hair Cortex | en_US |
dc.subject.other | DACM Staining | en_US |
dc.title | Pathogenesis of pili annulati | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Dermatology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Dermatology, University of Michigan Medical Center, Ann Arbor, Mich., USA | en_US |
dc.contributor.affiliationother | Department of Dermatology, Niigata University School of Medicine, 951, Niigata, Japan | en_US |
dc.contributor.affiliationother | Department of Dermatology, Niigata University School of Medicine, 951, Niigata, Japan | en_US |
dc.contributor.affiliationother | Department of Dermatology, Wayne State University School of Medicine, Detroit, USA; Veterans Administration Center, Allen Park, USA | en_US |
dc.contributor.affiliationother | Department of Dermatology, Niigata University School of Medicine, 951, Niigata, Japan | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 2460036 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47241/1/403_2004_Article_BF00440605.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00440605 | en_US |
dc.identifier.source | Archives of Dermatological Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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