Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney

Schacht, Jochen

1979-03

Citation: Schacht, Jochen; (1979). "Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney." Archives of Oto-Rhino-Laryngology 224 (1-2): 129-134. <http://hdl.handle.net/2027.42/47260>

Abstract: Affinity chromatography was used to isolate aminoglycoside receptors from inner ear tissues and kidney. Neomycin was immobilized on glass beads and served as the stationary phase in column chromatography. Fractionation of an organic tissue extract on this matrix demonstrated two components with high affinity for neomycin: phosphatidyl inositol phosphate and phosphatidyl inositol diphosphate. The toxicity of aminoglycosides is explained on the basis of a drug-interaction with these lipids.

ISSN: 0302-9530, 1434-4726

DOIs: http://dx.doi.org/10.1007/BF00455236

PMID: 226045

URI: http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=226045&dopt=citation

Handle: http://hdl.handle.net/2027.42/47260

Show full item record