S100 is preferentially distributed in myelin-forming Schwann cells
dc.contributor.author | Mata, Marina | en_US |
dc.contributor.author | Alessi, Diane M. | en_US |
dc.contributor.author | Fink, David J. | en_US |
dc.date.accessioned | 2006-09-11T18:56:58Z | |
dc.date.available | 2006-09-11T18:56:58Z | |
dc.date.issued | 1990-06 | en_US |
dc.identifier.citation | Mata, M.; Alessi, D.; Fink, D. J.; (1990). "S100 is preferentially distributed in myelin-forming Schwann cells." Journal of Neurocytology 19(3): 432-442. <http://hdl.handle.net/2027.42/47412> | en_US |
dc.identifier.issn | 0300-4864 | en_US |
dc.identifier.issn | 1573-7381 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47412 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2391542&dopt=citation | en_US |
dc.description.abstract | In order to elucidate the role of S100 protein in vivo we used postembedding electron microscopical immunocytochemistry with commercially available antibodies to S100, and secondary antibodies conjugated to colloidal gold to determine the distribution of S100 protein in the sciatic nerve and the cervical sympathetic trunk of the rat. We found that S100 immunoreactivity in Schwann cells was differentially distributed. The amount of S100 immunoreactivity in myelinated fibres appeared to correlate directly with the thickness of the myelin sheath formed by the Schwann cell. Unmyelinated fibres were identical to the small myelinated fibres in S100 immunoreactivity. Within the Schwann cells, the immunoreactivity was seen in the nucleus and in the perikaryal cytoplasm, as well as in the Schmidt-Lanterman clefts and in the paranodal loops at the node of Ranvier, but not in the myelin itself. Using these antibodies we did not see reproducible or convincing intra-axonal immunoreactivity in normal nerve. | en_US |
dc.format.extent | 6866858 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Chapman and Hall Ltd ; Springer Science+Business Media | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Neurosciences | en_US |
dc.subject.other | Neuroradiology | en_US |
dc.title | S100 is preferentially distributed in myelin-forming Schwann cells | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Neurology Research Laboratory, VA Medical Center and Department of Neurology, University of Michigan, Ann Arbor, MI, USA; Neurology (127), 2215 Fuller Road, 48105, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Neurology Research Laboratory, VA Medical Center and Department of Neurology, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Neurology Research Laboratory, VA Medical Center and Department of Neurology, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 2391542 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47412/1/11068_2005_Article_BF01188409.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01188409 | en_US |
dc.identifier.source | Journal of Neurocytology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.