A nonsense mutation in the structural gene for glutamine synthetase leading to loss of nitrogen regulation in Klebsiella aerogenes
dc.contributor.author | Bender, Robert A. | en_US |
dc.contributor.author | Eades, Linda J. | en_US |
dc.date.accessioned | 2006-09-11T19:06:42Z | |
dc.date.available | 2006-09-11T19:06:42Z | |
dc.date.issued | 1982-10 | en_US |
dc.identifier.citation | Bender, Robert A.; Eades, Linda J.; (1982). "A nonsense mutation in the structural gene for glutamine synthetase leading to loss of nitrogen regulation in Klebsiella aerogenes ." MGG Molecular & General Genetics 187(3): 414-418. <http://hdl.handle.net/2027.42/47550> | en_US |
dc.identifier.issn | 1617-4623 | en_US |
dc.identifier.issn | 0026-8925 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47550 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6129565&dopt=citation | en_US |
dc.description.abstract | An amber mutation ( glnA3711 ), the first nonsense mutation isolated in Klebsiella aerogenes , is described. When amber suppressors were present, the mutant made active glutamine synthetase which was more thermolabile than wild type, showing that glnA3711 lies in the structural gene for glutamine synthetase. Strains carrying the glnA3711 allele were unable to express nitrogen regulation of genes coding for histidase, asparaginase, and glutamate dehydrogenase unless amber suppressors were also present. These results support a model that expression of gene(s) from the glnA promoter is required for nitrogen regulation in K. aerogenes . | en_US |
dc.format.extent | 542996 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Cell Biology | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Microbial Genetics and Genomics | en_US |
dc.title | A nonsense mutation in the structural gene for glutamine synthetase leading to loss of nitrogen regulation in Klebsiella aerogenes | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Cellular and Molecular Biology, Division of Biological Sciences, University of Michigan, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 6129565 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47550/1/438_2004_Article_BF00332621.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00332621 | en_US |
dc.identifier.source | MGG Molecular & General Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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