Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization

Voorhees, John J.; Pettersson, Ulrika; Åström, A.; Elder, James T.; Trent, Jeffrey M.

1992-07

Citation: Elder, J. T.; Åström, A.; Pettersson, U.; Voorhees, J. J.; Trent, J. M.; (1992). "Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization." Human Genetics 89 (5): 487-490. <http://hdl.handle.net/2027.42/47631>

Abstract: Two highly conserved forms of cellular retinoic acid binding protein (CRABP-I and CRABP-II) have been described, and one, CRABP-II, is highly expressed in human skin. We have utilized a 10-kb fragment containing the human CRABP-II (hCRABP-II) gene (isolated from a human genomic library) to localize hCRABP-II to human chromosome 1 band q21 by fluorescence in situ hybridization. Localization to 1q was confirmed by hybridization of a hCRABP-II cDNA clone against a human-mouse hybrid cell line containing a t(1;6)(q21;q13) translocation chromosome. The hCRABP-II gene is therefore localized to a band known to contain several other genes that are expressed in the context of epidermal differentiation, including profilaggrin, loricrin, involucrin, and calcyclin.

ISSN: 1432-1203, 0340-6717

DOIs: http://dx.doi.org/10.1007/BF00219171

PMID: 1321791

URI: http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1321791&dopt=citation

Handle: http://hdl.handle.net/2027.42/47631

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