Wide excision without radiation for desmoplastic melanoma
dc.contributor.author | Arora, Alisha | en_US |
dc.contributor.author | Lowe, Lori | en_US |
dc.contributor.author | Su, Lyndon D. | en_US |
dc.contributor.author | Rees, Riley S. | en_US |
dc.contributor.author | Bradford, Carol R. | en_US |
dc.contributor.author | Cimmino, Vincent M. | en_US |
dc.contributor.author | Chang, Alfred E. | en_US |
dc.contributor.author | Johnson, Timothy M. | en_US |
dc.contributor.author | Sabel, Michael S. | en_US |
dc.date.accessioned | 2006-12-07T16:51:32Z | |
dc.date.available | 2006-12-07T16:51:32Z | |
dc.date.issued | 2005-10-01 | en_US |
dc.identifier.citation | Arora, Alisha; Lowe, Lori; Su, Lyndon; Rees, Riley; Bradford, Carol; Cimmino, Vincent C.; Chang, Alfred E.; Johnson, Timothy M.; Sabel, Michael S. (2005)."Wide excision without radiation for desmoplastic melanoma." Cancer 104(7): 1462-1467. <http://hdl.handle.net/2027.42/48756> | en_US |
dc.identifier.issn | 0008-543X | en_US |
dc.identifier.issn | 1097-0142 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/48756 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16080180&dopt=citation | en_US |
dc.description.abstract | BACKGROUND Adjuvant radiation has been proposed for the treatment of patients with desmoplastic melanoma, who reportedly have local recurrence rates as high as 40–60%. The authors investigated local recurrence rates at a tertiary referral center to determine the success of wide excision alone for patients with desmoplastic melanoma. METHODS A review of a prospectively maintained melanoma clinical data base identified 65 patients between March 1997 and March 2004 with pure cutaneous desmoplastic melanoma. Complete surgical, histopathologic, and staging information was collected along with data on outcome, including local, regional, and distant recurrence and survival. RESULTS Similar to previous reports, patients with desmoplastic melanoma had a male-to-female ratio of 2 to 1, a mean age of 65.0 years (range, 31–92 yrs), and the majority of their tumors (55%) were located on the head and neck. The mean Breslow depth at diagnosis was 4.21 mm, with 38% of tumors thicker than 4.0 mm. All patients in this series underwent wide excision without radiation therapy. Surgical margins ≤ 2 cm were obtained for all trunk and extremity lesions and for 63% of head and neck lesions that measured > 1 mm in depth (63%). Margins of 1–2 cm were obtained for the remaining patients. Among 49 patients who had a minimum of 2 years of follow-up (mean, 3.7 yrs), the local recurrence rate was 4% (2 of 49 patients). Seventy-eight percent of the patients studied remained alive with no evidence of disease. CONCLUSIONS Local recurrence rates in the current series were considerably lower than the historically reported rates. This finding suggests that, for patients with desmoplastic melanoma, wide local excision with careful attention to appropriate margins produces excellent local control rates without the need for adjuvant radiation. Cancer 2005. © 2005 American Cancer Society. | en_US |
dc.format.extent | 79659 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Wide excision without radiation for desmoplastic melanoma | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, Michigan ; Department of Dermatology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, Michigan ; Department of Dermatology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan, Ann Arbor, Michigan ; Department of Dermatology, University of Michigan, Ann Arbor, Michigan ; Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan, Ann Arbor, Michigan ; Fax: (734) 657-9647 ; 3304 Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48105 | en_US |
dc.identifier.pmid | 16080180 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/48756/1/21311_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/cncr.21311 | en_US |
dc.identifier.source | Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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